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Drs Piña and Borlaug discuss the CMR substudy from the SUMMIT trial of tirzepatide in HFpEF/obesity. How does weight loss affect pericardial fat and skeletal muscle? https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt --TRANSCRIPT-- Ileana L. Piña, MD, MPH: Hello. I’m Ileana Piña, from Thomas Jefferson University in Philadelphia, Pennsylvania, and this is my blog. It’s a little bit different blog because I’m really interviewing a good friend about these glucagon-like peptide 1 (GLP-1) inhibitors. Some of our heart failure patients are getting their GLP-1 inhibitors from their primary care physicians, but many questions have arisen with the trial called SUMMIT. With us today is Barry Borlaug, who is in charge of the research section with the cardiovascular section of Mayo, and that is Mayo, Rochester, where it must be much colder even than here in Philadelphia. Barry, congratulations on that trial. Tell our audience a little bit about how the trial was structured because it’s important how we get into your information. SUMMIT Recap Barry A. Borlaug, MD: Thanks, Ileana. SUMMIT was a randomized, double-blind, placebo-controlled trial, testing the GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Unlike some other trials, this was real HFpEF with an ejection fraction of 50% or above. Patients were randomized 1:1 to tirzepatide, titrated up to 15 mg once weekly, or placebo and treated for a minimum of 52 weeks. The dual primary endpoints were worsening heart failure or cardiovascular death and quality of life by the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. The median duration of follow-up was 2 years. We continued follow-up until the last patient enrolled completed the full 52-week period of treatment. We found that, as compared to placebo, tirzepatide reduced the risk of worsening heart failure or cardiovascular death by 38%, which was statistically significant, and also improved the KCCQ clinical summary score. In addition to that, we also looked at other patient-centered outcomes like 6-minute walk distance and biochemical markers like C-reactive protein (CRP). We saw that there was also a significant improvement in exercise function measured by 6-minute walk distance and about a 40% decrease in CRP levels. Piña: How long did the total trial last, including the time that the drugs were being administered? Borlaug: The longest duration of follow-up was 3 years, and the median follow-up was 2 years. Piña: Were any of these patients also on sodium-glucose cotransporter 2 ( SGLT2) inhibitors ? Borlaug: Yeah, a minority of patients were also on SGLT2 inhibitors, about 17%. Piña: What was the baseline KCCQ score? Borlaug: Very poor. A s you know, physician-reported heart failure severity often doesn’t agree with patient reports. Overall, 72% of the patients were judged by their physicians to have class II heart failure, but the mean KCCQ score was just over 53, so pretty severe patient-reported limitations or severe HFpEF. Despite this — and this is often the case in HFpEF and obesity-related HFpEF — the median N-terminal pro-B-type natriuretic peptide ( NT-proBNP) was only 175. Piña: I was very surprised at that. Very surprised. That really is low. That was NT-proBNP. That wasn’t BNP. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt

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STOP DOING HIIT CARDIO FOR FAT LOSS 🛑 Just because you’re sweating doesn’t mean you’re burning fat. FACTS ABOUT WALKING: • Burns 400-500 cals/10K steps • Preserves your hard-earned muscle • Zero recovery needed • Do it anywhere, anytime → This is sustainable fat loss WHY HIIT IS OVERRATED: • Spikes stress hormones • Eats away at muscle mass • Body needs recovery time • Can’t do it everyday → Your gains are crying LISTEN: I’m not saying never do HIIT. If you enjoy it, do it. But as a coach, here’s what I see: • Walking = sustainable results • HIIT = burnout city THE SIMPLE TRUTH: You don’t need to destroy yourself to lose fat. 10K steps will get you there while: • Keeping your muscle • Feeling energized • Actually sticking to it • Living a normal life Save this before the HIIT cult attacks me. P.S. Watch what happens when you track your steps instead of counting HIIT classes. Your body will thank you. This isn’t about working harder - it’s about working smarter. Drop a “🚶‍♂️” if you choose gains over unnecessary stress Note: Calorie burns vary by individual. This is based on averages and coaching experience.

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How to get lean? The process of getting lean and how to lose fat is actually very simple. It's not easy, but getting a lean body is 100% something anyone can do. If you follow my 3-part plan on how to get lean — from my fat loss diet and fat loss training training, as well as the crucial steps I took to prevent fat regain — I guarantee you’ll get lean fast and, more importantly, maintain your ‘shredded body’ for good. Click below for a step by step plan training plan that reveals all the best exercises you should do for each and every muscle group: https://quiz.builtwithscience.com/ Click below to subscribe for more videos: https://www.youtube.com/jeremyethier/?sub_confirmation=1 AI Animation Credit: https://youtube.com/@neuralplay?si=rv5pWLLTbgsS54YL But before we dive into the plan, there’s a key difference between 'leaning out' and 'getting a shredded body'. The reality is your body naturally resists getting too lean. It’s why dropping below even just to 12-15% body fat can start making you feel terrible and why most people who get that lean struggle to stay there. So if you are just starting out or don't have much dieting experience, aim for around 15-20%. And if you’re more experienced or have less fat to lose, aim for 12-15%. Those levels of leanness are still impressive and look fantastic, especially if you’ve built muscle along the way.  A recent study found that a more aggressive approach early on in the diet led to better fat loss results. So, how exactly did I apply this to get lean? Well, typically, during a diet, I’d eat around 2,300 calories. This time, however, the very first week of my diet, I ate just 1,200 calories a day. Now I HIGHLY recommend against this. I did this for an article to see how much belly fat I could lose in just 1 week. But, for the next 4 weeks after that, I still went aggressive. Eating just 1,900 calories a day. Surprisingly, it was easier than expected.  Until things started going downhill in the fifth week. But, because I had started with such a steep deficit in the beginning, I was able to increase my daily calories by 300 to continue slowly losing fat without ever feeling like my diet was becoming unsustainable However, regardless of whether you start out more aggressive or not when it comes to how to get lean, you’re going to have to eat fewer calories, and continue doing so for several weeks. Here’s exactly what I did to make my diet easy and enjoyable. Let’s start with the most important macronutrient. Protein. Eat enough protein every meal. As a simple guide, open your hand. The protein portion in each meal should be at least the size of your palm. But now, let’s talk about the big one when it comes to getting lean. Cutting calories.  You don’t have to eliminate carbs or fats entirely. Instead, it’s about modifying how much of them you eat. Tip: here’s how I made weekends work for me: a science-backed strategy called planned hedonic deviation (a fancy term for "treat meal”). Every Saturday or Sunday, I’d boost my intake by 500 to 800 calories to enjoy a big meal guilt-free. Sure, it technically slowed my weekly progress by a day, but it made sticking to the diet way more doable. But, of course, it’s not enough to just focus on your diet. Combining it with a proper training plan can not only help you get a lean body faster, but also plays a crucial role in keeping the fat off long-term. For strength training, the hardest muscles to grow also tend to be at the highest risk of loss during a diet. To counteract this, keep the volume high for those muscles. But you shouldn’t completely neglect any muscle groups. A new study released just this year found that muscles that aren’t trained will likely be burned off for energy. But lifting weights doesn’t burn nearly as many calories as you might think. The fewer calories you burn every day, the more you’ll have to cut from your diet, which makes sticking to it and getting lean a lot harder. But focus less on “cardio workouts” and just set a daily step goal. While 10,000 steps a day is often the recommendation, even for me that’s tough to fit into my schedule. So I aim for a more achievable 8,000 steps per day as my minimum.  So, I dropped about 1.5 lbs a week during the first 4 weeks with the more aggressive approach. Then, as expected, my progress slowed to about 0.5-1 lb per week in the last 4 weeks to get me down to 11.6% body fat. The plan definitely works. But it’s not just about getting lean, it’s also about how you can maintain your results. So, here are 3 mistakes to avoid. First, not accounting for your drop in metabolism. Second, not adjusting your lifestyle for the long haul. Third, not staying active post-weight-loss. That’s why, for me, those 8,000 steps a day didn’t just stop once I got lean. In fact, they became even more critical, especially with a slower metabolism. This is why setting a realistic step goal that you can stick to long-term is crucial.

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Semaglutides (like Ozempic & Wegovy) are changing the weight loss game—but how do they work? Dr. Truesdale breaks down the science behind these medications, how they curb appetite, and why so many people are seeing dramatic results in his latest video 🏃‍♀️✨ BUT… before you jump on the trend, there’s something you should know! Rapid weight loss can lead to "Ozempic Face"—a loss of facial volume that can make you look older. 😱 We’ll talk about why this happens and how to prevent it! Watch the full video here: https://youtu.be/FdPxrpMGR0w 🚨 What You’ll Learn: ✅ How semaglutides help with weight loss ✅ The pros & cons of using them ✅ Why "Ozempic Face" happens & what to do about it 💬 Have you tried semaglutides? Drop your thoughts below! 👇 And don’t forget to like, save & share for more insights! #Semaglutide #WeightLoss #OzempicFace #HealthTips #WellnessJourney Join this channel to get access to exclusive perks: https://www.youtube.com/channel/UCBnWgiJXDbtqLueAdrWok5w/join If you loved this video, give it a thumbs up and subscribe for more education, tips, and insights on facial plastic surgery and cosmetic procedures. Stay tuned for my upcoming show "Beyond the Surface," where I'll be diving deep into my life, patients, and practice. If you are interested in any cosmetic facial procedure in Beverly Hills, visit www.doctortruesdale.com or call Truesdale Facial Plastic Surgery at 424-363-4112. If you are interested in surgical and non-surgical education from Dr. Truesdale and his team, visit www.thetruesdaleacademy.com Follow Dr. Truesdale on IG @doctor.truesdale for the best facial plastic surgery content on the internet ;)

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Heartbreak and Transformation

The year 2024 marked a significant chapter in Vanessa Bryant’s life, a journey of transformation that was catalyzed by profound heartache. Following the tragic passing of her husband, Kobe Bryant, and their daughter Gianna in a helicopter crash in January 2020, Vanessa faced immense emotional turmoil. This heartbreak was compounded not only by the loss of her loved ones but also by the public scrutiny that often accompanied her life as a prominent figure in the media spotlight. This article chronicles how Vanessa turned her pain into a source of motivation, ultimately shedding an impressive 50 pounds and reclaiming her identity in the face of adversity. Through consistency, resilience, and dedication, Vanessa embarked on a journey that transcended mere weight loss; it became a transformative experience that focused on wellness, strength, and self-love.

Vanessa’s motivation for losing weight was not merely aesthetic. It stemmed from a deeper desire to honor her family’s memory and to ensure she remained healthy for her three daughters: Natalia, Bianka, and Capri. The process was undoubtedly challenging, filled with moments of doubt, fatigue, and temptation, but Vanessa’s commitment to a healthier lifestyle became a tribute to the resilience she admired in Kobe and Gianna. In those early days of her weight loss journey, every step felt monumental. The pain pushed her to strive harder, as she sought to create a meaningful legacy—one that emphasized strength through struggle.Diabetic Keto Acidosis Pharmacotherapy

During this journey, Vanessa also emphasized the importance of mental health and emotional well-being. She recognized that weight loss and physical fitness could not floury thrive in isolation; self-care, support systems, and mental fortitude were crucial as well. Whether through therapy, engaging in meaningful conversations with friends and family, or seeking solace in community, Vanessa made sure her process involved holistic healing. This multilayered approach is what transformed her life, allowing her to grow stronger while processing the deep pain of her losses. Without this emphasis on mental well-being, the journey might not have been as fulfilling or sustainable.

The Commitment to Healthy Living

Transitioning to a healthier lifestyle requires a paradigm shift, and for Vanessa Bryant, it started with a shift in her mindset. After grappling with heartbreak and the realities of life as a single mother, Vanessa made a commitment to prioritize her health. She began to see her body not just as something to lose weight from but as a vessel that deserved nourishment and care. This perspective allowed her to create a healthier relationship with food and exercise, moving beyond restrictive diets to sustainable lifestyle changes.

To achieve her weight loss goals, Vanessa incorporated a balanced diet into her routine. Working closely with nutritionists, she learned how to fuel her body effectively, focusing on whole foods, lean proteins, and healthy fats. This new approach allowed her to shed pounds without sacrificing her energy or joy around food. Vanessa also began to experiment with cooking at home, finding joy in preparing meals that were not only nutritious but also delicious. It became more than just weight loss; it transformed into an exploration of culinary creativity and a deeper understanding of nourishment.

Integrating fitness into her daily life was another pivotal aspect of Vanessa’s transformation. She sought the help of personal trainers and embraced various forms of exercise, from strength training to yoga and cardio. This diverse approach allowed her to enjoy her workouts while challenging her body in new ways. As she began to see results, her confidence soared, and Vanessa developed a new appreciation for what her body could achieve, inspiring her to push further and set new goals. Commitment to a healthy lifestyle, therefore, became a journey filled with empowerment and joy.

Inspirational Role Models and Support Systems

The journey of weight loss and transformation is rarely undertaken alone, and Vanessa’s community played a vital role in her success. She leaned on family and friends for support, embracing the communal aspect of her wellness journey. Vanessa often shared her challenges and triumphs with those closest to her, creating an accountability system that allowed her to stay focused and motivated. This support not only helped her manage setbacks but also celebrated her achievements, fostering a sense of togetherness that was as much about emotional healing as physical transformation.

In the world of celebrity and fitness, Vanessa also looked to other role models who inspired her journey. Whether through social media, press features, or personal encounters, she found motivation in the stories of others who had overcome significant challenges to achieve their goals. These narratives resonated deeply with Vanessa, reinforcing the idea that resilience, determination, and self-love are powerful tools in any transformative journey. It allowed her to see that even in moments of despair, there are ways to rise and thrive.

Additionally, Vanessa took advantage of various wellness communities, both online and offline. Engaging in fitness classes, workshops, and wellness events provided her with opportunities to meet like-minded individuals who were also on their health journeys. This connection enriched her experience and reminded her that she wasn’t just on a solitary quest. The friendships and bonds formed during this time acted as a network of positive reinforcement, showing her that collective growth could coexist with personal achievement.

Embracing a New Identity

As Vanessa Bryant shed the physical weight, she began to embrace a new identity—one that was empowered, strong, and connected. This transformation extended beyond appearance; it encapsulated a spirit of resilience and tenacity. With her new lifestyle, Vanessa found newfound energy and confidence that translated into all aspects of her life, from parenting to public engagements. As she navigated her role as a mother to her daughters and as a figure in the public eye, Vanessa began to articulate a narrative that focused on growth and healing.

The emotional liberation that accompanied her weight loss journey was significant. She learned to celebrate her body for its strength rather than its size, shifting the narrative around beauty and self-worth. This journey of self-acceptance allowed her to become an advocate for mental health and positivity following tragedy—a message she passionately shares with her followers and the public. Mental well-being became an integral part of her identity, leading her to use her platform to promote awareness and discussions surrounding grief, healing, and self-love.

Moreover, Vanessa began to see her story as a source of inspiration for others facing their own hardships. She actively participated in initiatives that aimed to uplift and empower women, sharing her journey to encourage them to embrace their challenges and find strength within themselves. This not only repositioned her narrative but also created a ripple effect—helping others recognize that transformation is possible even amid overwhelming adversity. The new identity she embraced became a beacon of hope and resilience for many.

Breaking Stigmas and Building a Legacy

As Vanessa continued on her path of transformation, she became acutely aware of the stigmas surrounding diet culture and body image. She used her platform to speak out against unrealistic beauty standards, advocating for a more inclusive and compassionate approach to health and wellness. By sharing her own story, Vanessa encouraged others to prioritize their mental well-being over societal pressures, creating a dialogue that resonates with many, especially in an age where social media can distort perceptions of beauty and success.

Building a legacy was also a significant aspect of Vanessa’s journey. Early on, she dedicated her transformation to Kobe and Gianna, finding ways to honor their memories through her actions and choices. This dedication fueled her desire to create impactful changes not just in her life but in the lives of others as well. In doing so, Vanessa established initiatives aimed at empowering women and children, ensuring that their legacy lived on through the work she did in the community.

Vanessa’s commitment to advocacy extended beyond her personal journey—she became actively involved in causes that matter to her, using her weight loss journey as a foundation to drive impactful change. Her voice became a unifying force, addressing the need for mental health resources and support, especially for those who have experienced trauma or loss. This multifaceted approach not only solidified her position as a leader in the community but also illustrated how one person’s transformation could uplift others facing similar challenges.

Reflections and FAQs on Vanessa’s Journey

Vanessa Bryant’s inspiring journey of losing 50 pounds in 2024 serves as a reminder of the power of resilience and determination. It illustrates how one can navigate profound sorrow and emerge transformed, both physically and emotionally. Those interested in following in Vanessa’s footsteps or understanding her process often have a plethora of questions. Here, we address some of the most common inquiries regarding her transformation journey.

Is Vanessa’s weight loss journey sustainable? Yes, Vanessa emphasizes sustainability over quick fixes. Through a balanced diet and exercise routine that she enjoys, she has established healthy habits that can be maintained long-term. This holistic approach ensures that she not only loses weight but ultimately gains strength and vitality.

How did Vanessa overcome challenges during her transformation? Vanessa leaned heavily on her community—friends, family, and support groups to help her navigate obstacles. Mindfulness, therapy, and self-reflection allowed her to manage setbacks healthily. She underscores the importance of seeking help and being open in sharing experiences with others.

What can others learn from Vanessa’s story? Vanessa’s journey serves as inspiration for many, illustrating that even through great sadness, one can choose to rise and transform. Her story is about more than weight loss; it’s about finding joy in resilience, embracing self-love, and creating a legacy that uplifts others. It encourages individuals to honor their journeys with authenticity and courage.

Can Vanessa’s advocacy work impact change? Absolutely. Vanessa’s advocacy resonates deeply with many, particularly regarding mental health awareness and resilience in face of hardship. By sharing her experiences and taking actionable steps in her community, she inspires others to take steps towards their own healing and transformation.

Ultimately, Vanessa Bryant’s weight loss and journey to wellness highlight the importance of community, perseverance, and self-love. In 2024, she emerged not just a lighter woman, but as a beacon of hope for many, proving that even in the face of heartache, one can find strength and purpose. Her story is, at its core, about navigating life’s challenges with grace, and turning personal tragedies into catalysts for positive change.

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In recent years, the ketogenic diet has gained immense popularity for its effectiveness in weight loss and overall health benefits. One of the pioneers of the keto movement is the original Keto from Shark Tank, a product that has become a household name in the health and wellness industry. As new keto products flood the market, it’s important to remember the legacy of the original Keto and the principles it was founded on. This article will explore the history of the original Keto, its impact on the keto movement, and why it remains a trusted brand for many keto enthusiasts.

The Birth of a Legacy

The original Keto from Shark Tank was born out of a desire to provide a simple and effective way for people to achieve ketosis, a metabolic state in which the body burns fat for fuel instead of carbohydrates. The founders of Keto understood the challenges of following a strict ketogenic diet and wanted to create a product that would make it easier for people to reap the benefits of ketosis without sacrificing taste or convenience.

After appearing on Shark Tank and receiving investment from the sharks, the original Keto quickly became a success story. Its unique formula, which includes a blend of high-quality ingredients such as MCT oil and collagen, set it apart from other keto products on the market. People were drawn to the simplicity and effectiveness of the original Keto, and word of mouth spread like wildfire.

As the keto trend continued to gain momentum, the original Keto remained a staple in the lives of many keto followers. Its loyal customer base praised its ability to help them stay in ketosis, boost their energy levels, and support their overall health goals. Despite the influx of new keto products, the original Keto held its ground as a trusted and reliable brand in the industry.

The Impact of the Original Keto

Over the years, the original Keto has had a profound impact on the keto movement. Its success story inspired a wave of entrepreneurs to create their own keto products, leading to a saturated market filled with a variety of options for keto enthusiasts. While this influx of products has provided consumers with more choices, it has also made it difficult to discern which products are truly effective and trustworthy.

Despite facing competition from new players in the market, the original Keto has maintained its reputation as a quality product that delivers on its promises. Its loyal customer base continues to sing its praises, citing its effectiveness in helping them achieve their weight loss and health goals. The original Keto stands as a testament to the power of simplicity and quality in a market that is often filled with gimmicks and fads.

As the keto movement continues to evolve, the legacy of the original Keto serves as a reminder of the importance of going back to basics. While it’s easy to get caught up in the latest trends and innovations, sometimes the simplest solutions are the most effective. The original Keto from Shark Tank remains a beacon of light in a sea of flashy products, standing as a testament to the principles of simplicity, quality, and effectiveness.

Remaining a Trusted Brand

What sets the original Keto apart from its competitors is its commitment to quality and transparency. While many keto products on the market cut corners and use fillers and additives, the original Keto prides itself on using only the highest quality ingredients. Each batch is carefully tested and formulated to ensure consistency and efficacy, giving consumers peace of mind that they are getting a product they can trust.

Another factor that sets the original Keto apart is its dedication to customer satisfaction. The founders of Keto understand the struggles that people face when trying to follow a ketogenic diet, and they have made it their mission to provide support and guidance to their customers. Whether it’s through informative articles, helpful tips, or responsive customer service, the original Keto goes above and beyond to ensure that their customers have everything they need to succeed on their keto journey.

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In conclusion, the original Keto from Shark Tank has left a lasting legacy in the world of health and wellness. Its simple yet effective approach to achieving ketosis has inspired countless people to embark on their own keto journeys. As the market continues to evolve, the original Keto remains a trusted brand that stands as a beacon of quality, transparency, and customer satisfaction. For anyone looking to go back to basics and reap the benefits of the ketogenic diet, the original Keto is a name they can trust.

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@HealthWithoutParadigms The 10 Most Effective Exercises for Weight Loss and Body Toning Discover the ultimate exercises to burn fat, tone muscles, and improve your overall health in a fast and safe way. In this video, we present the top 10 exercises recommended by fitness experts and backed by science. From light walking to high-intensity running, water aerobics, and weight training, each activity is carefully chosen to maximize calorie burn, boost cardiovascular health, and build muscle strength. Whether you’re a beginner or an experienced fitness enthusiast, these exercises can be adapted to your routine and require minimal equipment. Along the way, we clarify the difference between physical activity, exercise, and sports to help you better understand how to integrate these practices into your lifestyle. From fun sports like basketball and tennis to classic workouts like jumping rope and burpees, there’s something for everyone. Plus, we highlight the transformative benefits of weight training, not only for burning calories but also for preserving muscle mass and improving long-term health. With detailed calorie burn information and tips for incorporating these exercises into your life, this video is your guide to effective and sustainable fitness. Remember, consistency and proper guidance are key to achieving your goals. Don’t miss out—stay until the end to uncover the most surprising and effective exercise of all! Share this video with friends who are looking for fitness inspiration, and let us know in the comments which exercise you’ll try first. Let’s take the first step together toward a healthier, more active lifestyle!

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INSTAGRAM : @beerbiceps (https://www.instagram.com/beerbiceps/) TWITTER : @beerbicepsguy ( https://twitter.com/BeerBicepsGuy ) BEST and FASTEST Fat Loss Exercise: https://youtube.com/watch?v=7_7bR8P4UQA Namaste Dosto, Aaj main aapko bataunga how to lose stomach fat in Hindi ya how to burn belly fat in hindi. Agar aapko belly fat hai toh aapko cardio aura b exercises ko combine karna chahiye jiske vajah se aapke abs bhi badhenge aur belly fat bhi slowly kam ho jayega. Yeh video belly fat loss ko dhyaan me rakhke banayi gayi hai jo dekhke aapko samajh aa jaygi the best way to reduce belly fat aur how to get rid of belly fat. Sabse important baat aapko samajhna hoga who yeh ke aap ek jagah se fat burn nahi kar sakte. Aapko overall body ki fat ko kam karna hai toh aapko combine karna hoga cardio, ab training aur ek acch diet ko take aapka fat loss possible ho. Iss advice ko follow karoge toh aapka belly fat zaroor kam hoga aur aapke bhi abs dikhne lagenge. Hamesha ki tarah, health aur fitness pe aapko guide karne aa gaye hain aapke bade bhaiyya- Ranveer Allahbadia.