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This Harvard Medical School Continuing Education video examines these key questions: What role do GLP1 receptor agonists (GLP1 RA) play in weight loss? What are the risks and benefits of using GLP1 RA for weight loss? Lee-Shing Chang, MD, an endocrinologist at Brigham and Women’s Hospital, identifies FDA-approved medications for weight loss and explains GLP1 and the role GLP1 receptor agonists play in weight management. Key studies including the SCALE and STEP trials are highlighted and the efficacy of the GLP-1 receptor agonists liraglutide and semaglutide are compared. 00:00 | Introduction 00:37 | Pharmacotherapy for weight management 01:25 | What is GLP1 and what does it do? 02:35 | Clinical trials of liraglutide and semaglutide for weight loss This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content. References: Muskiet MHA, Tonneijck L, Smits MM, et al. GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes. Nat Rev Nephrol. 2017;13(10):605-628. doi:10.1038/nrneph.2017.123 Pi-Sunyer X, Astrup A, Fujioka K, et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015;373(1):11-22. doi:10.1056/NEJMoa1411892 Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989. doi:10.1056/NEJMoa2032183 Rubino DM, Greenway FL, Khalid U, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138-150. Rubino D, Abrahamsson N, Davies M, et al. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. JAMA. 2021;325(14):1414-1425. doi:10.1001/jama.2021.3224 Notice: At this time, the content in this video is not accredited.

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You’ve seen the headlines, the buzz, the seemingly miraculous results. Ozempic and other weight loss drugs are taking the world by storm, promising a path to a slimmer, healthier you. But what if there was a dark secret lurking behind these trendy medications? In this eye-opening video, we expose the hidden costs and potential dangers of weight loss drugs, diving deep into the complex web of influence that is shaping the landscape of healthcare. We explore the truth about Ozempic and other similar drugs, revealing how pharmaceutical companies often prioritize profits over your health, leaving consumers to deal with the fallout. You’ll discover: The real story behind Ozempic's rise to popularity The astronomical amount of money spent on weight loss drug marketing How these ads contribute to overdiagnosis and overtreatment The potential side effects and long term risks that are often downplayed The financial burden placed on consumers through exorbitant drug prices How Big Pharma exerts influence over media and public opinion What politicians, like Robert F. Kennedy Jr., are saying about this debate. We also compare the U.S. approach to prescription drug advertising to other countries, revealing how unique the U.S. system truly is. By the end of this video, you’ll be armed with critical knowledge to protect yourself from the influence of pharmaceutical marketing. Join us as we ask: Are you being ripped off by weight loss drugs? Is this really a solution, or just a new way for big pharma to profit off of our deepest insecurities? Don’t forget to LIKE, SHARE, and SUBSCRIBE for more truth-revealing content! Let your voice be heard! #Ozempic #WeightLossDrugs #BigPharma #PharmaceuticalAds #DrugSideEffects #Healthcare #DTCAdvertising #Overdiagnosis #MedicalTruth #PrescriptionDrugs #ConsumerProtection #HealthScams #DrugMarketing #HealthcareSystem #Obesity #WeightLossJourney #PharmaExposed

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