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Ozempic and Mounjaro are the two main GLP-1 medications used to treat Type 2 Diabetes. Wegovy and Zepbound are the two main GLP-1 medications used to treat obesity. GLP-1 medications account for 9% of an employer's prescription medication spend on average, yet only 1.7 percent of plan members are on GLP-1 medications. Twelve percent of US adults have type 2 diabetes and 42 percent of US adults are obese, so if only 1.7 of plan members are on GLP-1s, then their overall prescribing is just barely getting started. GLP-1 medications cost $9,000 to $10,000 per person per year after PBM discounts and rebates. They comprise two of the top four medications by total overall spend by employers. Strategies to Lower Spending on GLP-1s by Employers Include: 1) Prior Authorization - HOWEVER, if an employer chooses to only cover GLP-1 medications for plan members above a certain BMI, then the pharmaceutical manufacturers will refuse to pay them rebate dollars--thus raising the overall cost of the medications. 2) Step Therapy 3) Non-Coverage Alternatively, GLP-1 medications pose such a great financial burden to employers that they may agree to a single-payer healthcare system run by the Government as a way of addressing the problem. Sources: https://www.wtwco.com/en-us/insights/2024/02/glp-1-drugs-implications-for-employer-health-plans https://blog.ifebp.org/employer-coverage-of-glp-1-drugs-on-the-rise/ https://www.cnbc.com/2024/06/18/healthy-returns-more-us-employers-covering-glp-1s-for-weight-loss.html#:~:text=Roughly%20one%2Dthird%20of%20employer,member%20companies%20or%20public%20institutions. https://www.biopharmadive.com/news/employers-healthcare-cost-growth-2025-pharmacy-glp1s/724966/ https://www.businessgrouphealth.org/en/newsroom/news%20and%20press%20releases/press%20releases/2025%20employer%20health%20care%20strategy%20survey https://www.biopharmadive.com/news/eli-lilly-zepbound-obesity-sales-second-quarter-guidance/723679/ https://www.goodrx.com/classes/glp-1-agonists/glp-1-drugs-comparison AHealthcareZ is 400+ Healthcare Finance Educational Videos. 💥 BOOK: Check out Dr. Bricker’s Book 16 Lessons in the Business of Healing here: https://www.ahealthcarez.com/healthcare-money-campfire-stories-book AHealthcareZ Viewers Include: Employee Benefits Professionals, HR, CFOs, Insurance Brokers, Benefits Consultants, Doctors and Nurses in Leadership Roles, Hospital and Health System Administrators, Health Insurance Carrier and PBM Professionals, Pharma and Med Device Professionals, Academic Professors and Students in Healthcare Administration and Public Health. 90,000+ Views Per Month Across All Platforms. 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On the other hand, tirzepatide is a newer medication that is also showing promise in promoting weight loss. In a recent study published in the Lancet, researchers found that individuals taking tirzepatide lost an average of 12% of their body weight over a 40-week period. While not as potent as semaglutide, tirzepatide still offers a significant amount of weight loss for individuals struggling to lose weight through diet and exercise alone. Overall, both semaglutide and tirzepatide have been shown to be effective in promoting weight loss. However, semaglutide may offer slightly greater weight loss results compared to tirzepatide. Side Effects Like all medications, semaglutide and tirzepatide can cause side effects in some individuals. The most common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to improve over time as the body adjusts to the medication. Similarly, tirzepatide can also cause gastrointestinal side effects such as nausea, vomiting, and diarrhea. In addition, tirzepatide has been associated with an increased risk of hypoglycemia (low blood sugar) in individuals with diabetes. It is important for individuals taking tirzepatide to monitor their blood sugar levels closely and talk to their healthcare provider if they experience any symptoms of hypoglycemia. Overall, both semaglutide and tirzepatide have similar side effect profiles, with gastrointestinal issues being the most commonly reported side effects. It is important for individuals considering these medications to discuss the potential side effects with their healthcare provider before starting treatment. Cost Another factor to consider when comparing semaglutide vs tirzepatide for weight loss is the cost of the medications. Semaglutide is currently available as a brand-name medication, Ozempic, which can be expensive for individuals without insurance coverage. However, a generic version of semaglutide is expected to become available in the near future, which may help reduce the cost of the medication for some individuals. On the other hand, tirzepatide is also a brand-name medication and may be expensive for individuals without insurance coverage. The cost of tirzepatide may vary depending on the dosage and frequency of administration prescribed by a healthcare provider. It is important for individuals considering tirzepatide to check with their insurance provider to determine coverage for the medication. Overall, the cost of semaglutide and tirzepatide may be a deciding factor for some individuals when choosing between the two medications. It is important to consider the cost of the medications in conjunction with their effectiveness and side effects when making a decision. 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Many individuals have turned to medications like semaglutide to aid in their weight loss journey. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that has shown promising results in helping individuals shed excess pounds. In this article, we will explore the effects of semaglutide before and after weight loss, diving into how this medication works, its potential benefits, and what individuals can expect when using it. How Semaglutide Works Semaglutide works by mimicking the effects of a hormone called GLP-1 that is naturally produced by the body. GLP-1 helps regulate blood sugar levels, increase feelings of fullness, and slow down digestion. By activating GLP-1 receptors in the body, semaglutide can help individuals eat less, feel satisfied with smaller portions, and ultimately lose weight. It also helps the pancreas release insulin in response to meals, which can improve blood sugar control in individuals with diabetes. When taken as an injection once a week, semaglutide can help individuals achieve significant weight loss over time. Studies have shown that patients who took semaglutide lost more weight compared to those taking a placebo. Additionally, semaglutide has been shown to reduce the risk of developing obesity-related conditions such as type 2 diabetes and high blood pressure. One of the reasons semaglutide is effective for weight loss is its impact on appetite regulation. By increasing feelings of fullness and reducing cravings, individuals may find it easier to adhere to a healthier diet and make better food choices. Semaglutide can also help improve metabolic health by reducing fat accumulation in the liver and promoting the use of stored fat for energy. Potential Benefits of Semaglutide In addition to weight loss, semaglutide has been associated with other health benefits that can improve overall well-being. For individuals with type 2 diabetes, semaglutide can help lower blood sugar levels and reduce the need for other medications to manage the condition. This can lead to better glycemic control and a decreased risk of diabetes-related complications. Furthermore, semaglutide has been shown to improve cardiovascular health by reducing the risk of heart attacks, strokes, and other cardiovascular events. This is especially important for individuals with obesity, who are at a higher risk of developing heart disease and other cardiovascular conditions. By promoting weight loss and improving metabolic health, semaglutide can help individuals reduce their cardiovascular risk factors and live healthier lives. Another potential benefit of semaglutide is its impact on overall quality of life. Losing weight and improving metabolic health can boost self-confidence, energy levels, and mood. Individuals may find that they have more motivation to engage in physical activity, socialize with others, and pursue their goals when they feel better physically and emotionally. What to Expect When Using Semaglutide Before starting semaglutide, individuals should consult with their healthcare provider to determine if this medication is suitable for them. It is important to discuss any underlying medical conditions, current medications, and weight loss goals to ensure that semaglutide is safe and effective. Healthcare providers can also provide guidance on how to inject semaglutide properly and monitor for any potential side effects. When using semaglutide, individuals can expect to see gradual weight loss over time, with most studies showing significant results within a few months of starting treatment. It is important to follow a healthy diet, engage in regular physical activity, and make lifestyle changes to maximize the benefits of semaglutide. Some individuals may experience side effects such as nausea, vomiting, or diarrhea, but these symptoms typically improve over time as the body adjusts to the medication. Overall, semaglutide can be a valuable tool for individuals looking to lose weight and improve their health. By working with healthcare providers, making lifestyle changes, and staying consistent with treatment, individuals can achieve meaningful results with semaglutide and enjoy a healthier, happier life. Semaglutide may be a new player in the weight loss game, but its effectiveness has already been making waves. If you’ve been considering semaglutide as a solution for your weight loss goals, read on to find out more about how this medication can help you achieve the results you desire. 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