Transcript Glp1 Won Do It All For You The Truth About Sustainable Weight Loss After 45Drs Piรฑa and Kosiborod discuss semaglutide in obesity-related HF with and without diabetes. Both STEP HFpEF trials show similar HF benefits despite less weight loss in patients with diabetes. https://www.medscape.com/viewarticle/semaglutide-benefits-hfpef-take-step-beyond-weight-loss-2024a10006z2?src=soc_yt -- TRANSCRIPT -- Ileana L. Piรฑa, MD, MPH: Hello, and welcome to my blog. Today, I'm at the American College of Cardiology in Atlanta. I want to introduce and welcome Dr Kosiborod: from the Mid America Heart Institute, who has presented a very impactful paper, STEP HFpEF DM, that is in The New England Journal of Medicine right now. This is about semaglutide. A lot of patients ask me to give them that pill that makes them lose weight. I see primarily patients with heart failure (HF). So, Mikhail, congratulations on your presentation. Give us a little synopsis of what the trial is about. The STEP HFpEF Program Mikhail N. Kosiborod, MD: First of all, it is always a pleasure to be with you. Maybe a quick word about the STEP HFpEF program that included two trials: The first is STEP HFpEF, which was a trial of patients with obesity-related HF with preserved ejection fraction (HFpEF) who did not have diabetes, which we presented and published at European Society of Cardiology in August last year. The second installment of the program is the STEP HFpEF diabetes trial, which is essentially the same population of patients except they also have type 2 diabetes. I guess your question would be why we did two trials instead of just doing one trial that included patients, both with and without diabetes. I'll come back to that shortly. The crux of the hypothesis behind the program is that we all know the prevalence of HFpEF has increased dramatically in the past couple of decades. When I was a fellow in training, it was rare for me to see a patient with HF who had preserved EF. A majority of patients had HF with reduced EF. Now, the majority of people we see have HFpEF: Why did that happen? There are a lot of different reasons for the dramatic change in epidemiology. But certainly, one of them, at least in our opinion, is that the obesity epidemic has a lot to do with it. In fact, if you look at the population of patients with HFpEF in the United States, 80% of them are living with overweight or obesity. The hypothesis behind the program was that obesity is not just a comorbidity. It doesn't just happen to coexist by accident in this patient population, it may in fact be causing their HF. It may be a critical factor in the development and progression of HFpEF. In order to test our hypotheses, patients were randomly assigned to semaglutide, with the target dose of 2.4 mg once a week or matching placebo and treated for 52 weeks, or 1 year. The reason we did two separate trials is because part of that hypothesis was that if obesity is in fact the cause of HF, then certainly, weight loss would be probably not the only factor but "an important factor in the potential benefits of semaglutide in this patient population, provided that semaglutide is beneficial which of course we ultimately demonstrated. But what we knew from weight-loss trials โ not HF trials but weight-loss trials of medications like semaglutide and also other anti-obesity medications like tirzepatide and others โ is that people with diabetes tend to lose a lot less weight. With these medications, there's about a 40% less weight loss in people with type 2 diabetes. Lots of theoretical reasons why that could be the case. Nobody really knows for sure. We knew from the beginning that the weight loss likely was going to be different. Then, of course, there are other things that happen in people with diabetes: They have more severe HFpEF phenotype, and people with more severe disease sometimes don't respond to treatment the same way as those with less severe disease. Finally, we knew when we started the trial, which was back around 2019, 2020, that people with diabetes would be more likely to be treated with sodium-glucose cotransporter 2 (SGLT2) inhibitors. At the time, we didn't have the data for SLT2 inhibitors in HFpEF, but we knew that were going to be tested. There was, of course, an expectation that they may well be beneficial. For all of these reasons, we said, "You know what, the treatment effects may well be different between the patient population, but let's study them separately." Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/semaglutide-benefits-hfpef-take-step-beyond-weight-loss-2024a10006z2?src=soc_ytKeto Acv Gummies Price Investing In Your Ketosis JourneySome people see an increase in their LDL cholesterol when they eat a keto diet or carnivore diet but is this cause for concern? High cholesterol on keto is not unusual and might not mean you are at a greater risk of heart disease. Triglyceride to HDL ratio can be more significant. ๐๐๐๐๐ ๐ง๐ข ๐ฅ๐๐๐ ๐ ๐ข๐ฅ๐ โ Find your triglyceride to HDL ratio https://www.thebloodcode.com/calculators/ https://www.tandfonline.com/doi/full/10.1080/17512433.2018.1519391?journalCode=ierj20&scroll=top&needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664115/ https://bmjopen.bmj.com/content/6/6/e010401 https://pubmed.ncbi.nlm.nih.gov/26109578/ https://cardiab.biomedcentral.com/articles/10.1186/s12933-018-0762-4 https://pubmed.ncbi.nlm.nih.gov/19437396/ โโโโโโโโโโโโโโโโโโโโโโโโโโ 0:00 Intro 1:32 What is cholesterol? 2:34 Types of cholesterol 3:14 Cholesterol and heart disease 4:44 Triglyceride to HDL ratio 6:38 Why does LDL increase? 8:07 My cholesterol 9:56 Calculating TRIG:HDL โโโโโโโโโโโโโโโโโโโโโโโโโโ โ ๐๐ผ๐๐พ๐ ๐๐๐๐ โ How to raise HDL cholesterol https://youtu.be/57Kpom1BUDk Saturated fat vs unsaturated fat https://youtu.be/W2aMmRr9gfM What breaks a fast? https://youtu.be/lWMiLlejTy0 โโโโโโโโโโโโโโโโโโโโโโโโโโ โ ๐พ๐๐ผ๐พ๐๐๐๐ โ Insulin Resistance Masterclass + Meal Plan https://hckait.com/IRmasterclass Other programs https://hckait.com/coaching โโโโโโโโโโโโโโโโโโโโโโโโโโ โ ๐๐๐๐ โ Support the channel and get extra perks! โค https://hckait.com/join My second channel https://youtube.com/c/morekait โโโโโโโโโโโโโโโโโโโโโโโโโโ โ ๐พ๐๐๐๐๐พ๐ โ TikTok https://hckait.com/tiktok Instagram https://hckait.com/instagram Twitter https://hckait.com/twitter Facebook https://hckait.com/facebook Pinterest https://hckait.com/pinterest Website https://healthcoachkait.com โโโโโโโโโโโโโโโโโโโโโโโโโโ โ ๐๐ผ๐๐ ๐๐๐พ๐๐๐๐๐๐ฟ๐ โ BEEF LIVER CAPSULES 10% off: KAIT10 http://hckait.com/grasslandnutrition COLLAGEN POWDER 10% off: HCK10 https://hckait.com/nutracollagen REAL SALT 15% off: KAIT15 https://amzn.to/4bgF1C7 BLUE LIGHT BLOCKING GLASSES 15% off: HCK15 https://hckait.com/boncharge RED LIGHT DEVICE 15% off: HCK15 https://hckait.com/rlt KRILL OIL 15% off: HCK15 https://hckait.com/krill BONE BROTH 10% off: KAIT https://hckait.com/kettleandfire ELECTROLYTES 15% off: KAIT15 https://hckait.com/sodiielectrolytes โโโโโโโโโโโโโโโโโโโโโโโโโโ This video is for general informational purposes only. It must never be considered a substitute for the advice provided by a doctor or other qualified healthcare professional. Always seek the advice of your physician or other qualified healthcare professional with questions you may have regarding your health or medical condition. This video is not sponsored. Some of the links above are affiliate links which means I make a small commission when you shop through them at no extra cost to you. I do not align myself with any brand that I do not 100% love and trust. #cholesterol #ketodiet #carnivorediet2 Hacks To Eat Rice And Lose Fat Weightloss Hacks Myths FitnessBuy Doctor's Choice Bulking : - Website : https://thedrchoice.com/products/bulk-king-mass-gainer - Amazon : https://tinyurl.com/4npnj83f - Follow Me On Instagram : https://www.instagram.com/rohitkhatrifitness/?hl=Where To Buy Legends Keto Legends Keto Diet PillsWhat is Keto? Beginner's Guide to Ketogenic Diet for Weight Loss & Energy Dive into the world of the ketogenic diet! 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Join this channel to get access to perks: https://www.youtube.com/channel/UCDrS2uK6y7UbxAvikx5NmzA/join โ Amazon Page https://www.amazon.co.uk/shop/sassyj?ref_=cm_sw_r_mwn_aipsfshop_aipsfsassyj_3D864K4SW09AGK7BWVZ8 โ Contact Email: [email protected] (For business/partnership enquiries only FTC Legal Disclaimer - Some links found in the description box of my videos maybe affiliate links, meaning I will make commission on sales you make through my link. This is at no extra cost to you to use my links/codes, it's just one more way to support me and my channel. :)Obesity Weight Loss Dr Venkatramana Hegde Veda Wellness Center Nisarga Mane Sirsi Exploring Eugenia Cooneyโs Journey Before Weight Loss Eugenia Cooney is a well-known figure in the online community, particularly among those who are involved in beauty, fashion, and lifestyle content. She rose to fame through her YouTube channel, where she showcased her unique style and personality. However, her journey has also been marked by significant challenges related to her health and body image, drawing attention and concern from her fans and beyond. Before her weight loss journey, Eugenia exhibited a distinctively slender appearance that sparked both intrigue and worry among viewers. This article aims to delve deeper into Eugenia Cooneyโs life before her notable weight loss, highlighting three shocking images from that time, while also addressing the implications of body image and mental health issues in todayโs society. Initially, Eugeniaโs rise to fame was accompanied by substantial online support, but there were also negative comments and concerns regarding her physical appearance. Many fans expressed worry about her health, leading to debates about the responsibilities of influencers regarding body image and the impact of online communities on individuals facing similar challenges. It is important to understand that figures like Eugenia can influence public perception of beauty, and the reactions to her appearance before weight loss indicate a larger societal issue that needs to be addressed. The dialogue surrounding body positivity and mental health is critical, especially in an era where social media bombardment can lead to unrealistic expectations of beauty and lifestyle. Moreover, the visibility of celebrities and influencers, who typically present curated versions of themselves online, can create pressure for individuals to conform to specific beauty standards. Eugeniaโs journey resonates with many, as it highlights the complexities of mental health, self-acceptance, and societal pressures. It is vital to analyze how the images of Eugenia Cooney before her weight loss reflect not only her personal struggles but also the broader conversation about the pressures faced by individuals, particularly women, regarding body image. Understandably, this resonates with the interests of audiences seeking deeper connections with their favorite influencers, especially those who have undergone transformative experiences. Shocking Image One: A Candid Snapshot The first shocking image weโll examine is a candid snapshot that captures Eugenia Cooney in a natural setting, showcasing her physical state during a time when her weight was a significant concern. This image reveals a frail appearance, epitomizing the struggles that accompanied her ongoing battles with self-image and mental health. In this photograph, the contrast between her vibrant personality and the fragility of her physical state becomes starkly evident. Viewers can perceive an underlying struggle, hinting at the broader issues surrounding mental health and body image that she faced at that time. Moreover, this particular image has been discussed extensively among fans and mental health advocates. It serves as a gateway for discussions about the importance of addressing eating disorders and the need for better understanding and support for those who may be suffering. The emotional weight of the image goes beyond mere aesthetics; it invites critical reflections on the importance of self-love and the need for a supportive community that fosters body positivity. Finally, this shocking snapshot prompts conversation about the role social media can play in influencing individualsโ perceptions of beauty. For many young people, these images can lead to unhealthy comparisons, impacting their self-esteem. As viewers reflect on Eugeniaโs candid photo, it serves as a reminder of the necessity for compassion, awareness, and constructive dialogue surrounding mental health and body image issues, particularly within the fast-paced world of digital content creation. Shocking Image Two: The Contrasting Celebrity Glamour The second striking image depicts Eugenia in a glamorous setting, showcasing her talent for fashion and style. Wearing an eye-catching outfit, the contrast between this glamorous presentation and her underlying struggles adds depth to her story. In this image, Eugenia appears confident, embodying the ideals typically associated with beauty influencers, which can mislead viewers about her overall well-being. The layers of glamour in the photo juxtapose the realities of her mental health struggles, emphasizing how multifaceted the narrative around body image can be. This image highlights the dichotomy between public perception and private experience. While many audiences focus solely on the eye-catching appearance, it is essential to reflect on Eugeniaโs personal narrative, comprising battles with self-doubt and feelings of inadequacy. The glamourmask that these images often hold can obscure the genuine struggles that many individuals, including influencers, face behind closed doors. It underscores the idea that even those who seem to have it all together may grapple with inner turmoil. Furthermore, this contrast nurtures discussions around authenticity in the influencer space. Followers may question the disparity between an influencerโs portrayed image and their challenging reality. This serves as a vital opportunity for influencers to promote honesty and sincerity in their content, fostering an environment where mental health conversations can thrive. Recognizing this tension in images not only elevates Eugeniaโs narrative but also brings broader issues about representation, authenticity, and mental well-being into the light, encouraging a more profound reflection among audiences about their engagement with influencer content. Shocking Image Three: A Vulnerable Moment Captured The third shocking image captures a rare moment of vulnerability for Eugenia, showcasing her without the typical layers of makeup and styling associated with her online persona. This unfiltered portrayal serves as a powerful reminder of her humanity, stripping away the glamor to reveal the struggles she faced at that time. The rawness of this image resonates with audiences, reminding them that even influencers experience moments of self-doubt and vulnerability, battling the same insecurities that many face daily. This vulnerable snapshot plays a crucial role in conversations about mental health awareness and self-acceptance. By showing a side of herself that is less polished and more authentic, Eugenia invites viewers into her world, promoting a message that is often overlooked in the beauty and influencer sector: that it is okay to not always look perfect. This honesty creates space for discussions surrounding mental health and the standards imposed by society, encouraging followers to embrace their imperfections and seek help when needed. Moreover, the timing of this image within her journey is also noteworthy. It demonstrates a pivotal moment in her life that many can relate to, where external pressures can make it challenging to stay true to oneself. This photograph encourages important dialogues about mental well-being, authenticity, and the importance of building supportive communities centered around understanding and acceptance. As followers engage with this image, they are reminded of the significance of empathy towards public figures who face similar struggles behind the public facade, fostering a more compassionate outlook towards the challenges of life. Understanding the Impact of Online Representation The impact of online representation on body image has become a critical topic of discussion in contemporary society. Influencers like Eugenia Cooney have a significant following, and their images can greatly influence young audiences, shaping perceptions of beauty and self-worth. This representation can either promote positive body image narratives or contribute to unhealthy standards that create pressure to conform. As followers view stylized images, it can lead to an unrealistic representation of beauty, often resulting in harmful self-comparisons for viewers. Furthermore, this phenomenon can exacerbate feelings of inadequacy and low self-esteem among young people, leading to mental health challenges. As audiences consume curated online content, it is vital for influencers to recognize their responsibility in fostering body positivity and acceptance. Providing a more realistic portrayal of their experiences can help mitigate the adverse effects associated with idealized beauty standards while advocating for mental health awareness in the digital space. The dialogue surrounding body image continues to evolve, emphasizing the importance of diverse representation in media. It is essential for individuals, especially influencers, to promote narratives and imagery that reflect varied body types, experiences, and journeys. Engaging in this broader conversation can help to create a healthier environment in the social media landscape, encouraging inclusivity and acceptance beyond conventionally celebrated standards of beauty, ultimately benefitting the mental well-being of audiences. Reflecting on the Importance of Mental Health Awareness Reflecting on Eugenia Cooneyโs experience, it is evident that mental health awareness plays a pivotal role in addressing the challenges surrounding body image and self-acceptance. Her journey emphasizes the significance of prioritizing mental health, not just for public figures but for everyone. Acknowledging the struggles associated with mental health is crucial in fostering an environment where individuals feel supported and understood. As more conversations arise around mental health, it is essential to remove the stigma surrounding these topics, creating openness that encourages individuals to share their experiences without fear of judgment. Education and outreach remain integral in addressing mental health issues. Through awareness, individuals become equipped with the tools necessary to support themselves and others in crisis, transforming the conversation surrounding mental health into one of proactive care. Influencers like Eugenia can play an essential role in leading these discussions, using their platforms to advocate for mental health resources and support systems. By sharing their own journeys, they can encourage others to seek help, realize they are not alone in their struggles, and understand that road to recovery is a valid and important journey. Ultimately, the overarching message concerning Eugenia Cooneyโs story is one of hope and resilience. Through awareness and support, individuals can navigate their battles with mental health and body image. By promoting compassion, understanding, and acceptance, societies can foster an inclusive space that values each personโs unique story and experience. This journey towards acceptance not only impacts individualsโ lives positively but also enhances the dialogue around body image and self-worth throughout communities. Summary and Common Questions Addressed In summary, Eugenia Cooneyโs experience before her weight loss reflects the complexities surrounding body image and mental health within the influencer sphere. Through analyzing three shocking images, one can observe the differences between public perception and private reality, highlighting the struggles many face in the pursuit of acceptance. These images serve as pivotal conversation starters regarding mental health, authenticity, and the impact of online representation, especially for young audiences navigating similar challenges. Many viewers may have questions about the broader implications of Eugeniaโs story, particularly concerning mental health. One common question is how to balance social media engagement with mental well-being. It is essential to curate content thoughtfully, seeking out positive representations and limiting exposure to idealized images that may lead to harmful comparisons. Engaging in positive online communities that advocate for body positivity can significantly improve oneโs experience. Another frequent inquiry revolves around what individuals can do to help someone struggling with body image issues. The key is to create an open dialogue that promotes honesty and understanding. Encouraging discussions about mental health can help dispel stigma while fostering trust and support. 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