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Specifically, the study found that keto increased the expression of SIRT1, which led to a reduction in the genes responsible for nephropathy. In indications of energy surplus, such as glycogen and insulin, inhibit activation of AMPK - ketosis decreases these factors that inhibit AMPK. Through a very long process ketosis is able to activate SIRT1 indirectly through activation of AMPK. https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2781128 SIRT1: SIRT1 is a protein or vehicle that requires NAD+ to function - SIRT1 takes acetyl groups off of proteins. SIRT enzymes “turn off” certain genes that promote aging, such as those involved in inflammation, in fat synthesis and storage, and in blood sugar management. When proteins are undergoing stress, acetyl groups are added to proteins as a response to changes induced by inflammation and oxidation. Sirtuins (like SIRT1) remove these acetyl groups to keep the protein in service longer than usual, while simultaneously stabilizing the charge state of the carbon backbone in protein to resist any further changes in their shape. This allows your cellular proteins to live longer and you can save energy on other processes. Keto & Glomerular Lesions: Glomerular filtration rate (GFR) is a test to measure how well the kidneys filter blood and remove waste. Glomeruli, the small units within the kidney where blood is filtered - they act as tiny filters within the kidneys and each kidney contains millions of glomeruli. If the glomeruli become damaged, the kidney can no longer remove waste and excess fluids efficiently - blood and protein cannot be filtered and are excreted in the urine. Too much glucose may cause glomerular lesions in patients with poor glucose control, leading to impairment of the kidneys. Glomerulonephritis, a group of diseases that cause inflammation and damage to the kidney's filtering units - glomerulonephritis refers to a range of inflammatory kidney conditions of the tiny blood vessels in the kidneys. High glucose levels are thought to make the blood flow into the kidney at a higher speed, putting a strain on the filtering process and raising blood pressure. The capillaries in the glomerulus collapse and can leave the glomeruli with scarring. Meta Analysis - British Journal of Nutrition: The review measured the impact of low carb diet on renal function taking into account 1000 people from nine randomised controlled trials found that: “a low carbohydrate diet and the corresponding high-protein diet was not harmful for renal function in overweight and obese individuals without renal dysfunction.” Furthermore, it concluded that a low carb diet may even improve renal function thanks to its weight loss effects. References: 1) Impact of low-carbohydrate diet on renal function: a meta-analysis of over 1000 individuals from nine randomised controlled trials. (2016, August 28). Retrieved from https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/impact-of-lowcarbohydrate-diet-on-renal-function-a-metaanalysis-of-over-1000-individuals-from-nine-randomised-controlled-trials/0EAA25E700C06D2C5125F0AB195FB33F 2) University of Wisconsin Hospitals and Clinics Authority. (2010, June 24). How Do Kidney Stones Form? Retrieved from https://www.uwhealth.org/urology/how-do-kidney-stones-form/11210 3) Nesbitt, H. (n.d.). Kidney Week. Retrieved from https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2781128 4) Hong Q , et al. (n.d.). Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/29477240 5) Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health. (2018, February 11). Retrieved from https://www.hindawi.com/journals/jnme/2018/5157645/Mitolyn Reviews Does Mitolyn Work Mitolyn Weight Loss Supplementhttp://weightlossprograms.tv is the organized approach to your successful goal weight. With the proven and potential negative side affects of pills, potions and prescriptions for weight loss, many people will only consider natural weight loss.How To Maintain Weight Loss After Semaglutide Tips For Longterm SuccessBest Weight Loss Supplements - Phen375 Weightloss Pill More info visit http://bit.ly/19scoNR I found a diet pill which have proven successful for thousands of individuals. People just like you have lost weight quickly and safely. Successful Phen375 weight-loss clients have written thousands of testimonials. Your only risk is losing weight! 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I believe taking them regularly for a long period could create some problems. 98% of vitamins sold are made synthetically. Just because synthetic vitamins are similar to natural vitamins doesn’t make them as healthy. Even the actual form of a synthetic vitamin is different from a natural vitamin. A few main problems with synthetic vitamins: • They have a low absorption rate • They don’t contain all of the cofactors that come with vitamins in nature • They have residual traces of solvents and chemical compounds • Synthetic fat-soluble vitamins have some significant potential side effects • They can contain additives, preservatives, flavorings, and colorings Consuming nutrient-dense foods is the best way to get your vitamins and nutrients. But, it can be difficult to find foods that contain all of the nutrients you need. Natural vitamin supplements have a lot fewer side effects and are much more bioavailable than synthetic supplements. They also come in their natural complexes and don’t contain harmful chemicals, solvents, additives, etc. that could be in synthetic vitamins. One way to identify a synthetic vitamin supplement is to look at the RDAs on the label. If the RDAs are in very high amounts, you know it’s probably synthetic. In nature, you will see varying degrees of amounts, so if everything across the board is 100%—you know it’s probably a synthetic supplement. Overall, there can be some pros to certain synthetic vitamins, but there are definitely some cons. Not to mention, there are way more pros when you consume natural whole-food vitamins. If you can go for the natural vitamins—do it. Even better yet, consume nutrient-dense foods. Check out my other videos for more information about a healthy diet and nutrient-dense foods. FREE COURSE➜ ➜ http://bit.ly/BulletproofImmuneSystemCourse Dr. Eric Berg DC Bio: Dr. Berg, age 57, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media. Follow Me On Social Media: Facebook: https://bit.ly/FB-DrBerg Instagram: https://bit.ly/IG-DrBerg TikTok: https://bit.ly/TikTok-DrBerg DR. BERG'S SHOP: http://shop.drberg.com/ ABOUT DR. BERG: https://www.drberg.com/dr-eric-berg/bio Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients so he can focus on educating people as a full time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. #keto #ketodiet #weightloss #ketolifestyle Thanks for watching! I hope this helps explain why you should avoid synthetic vitamins if possible. I’ll see you in the next video.Video Green Tea Weight Loss Supplements Could Be Dangerous Semaglutide is a new medication that has gained popularity for its potential to aid in weight loss. This drug was originally developed to treat type 2 diabetes but has been found to have significant effects on weight reduction. If you’re looking to try Semaglutide for weight loss, it’s important to understand the process and steps involved in obtaining this medication. Consultation with a Healthcare Provider The first step in getting Semaglutide for weight loss is to schedule a consultation with a healthcare provider. A doctor will assess your medical history, current medications, and weight loss goals to determine if Semaglutide is the right fit for you. They will also discuss potential side effects and proper usage of the medication. During the consultation, it’s important to be transparent about your health concerns and goals. Your doctor may recommend alternative weight loss strategies or medications based on your individual needs. If Semaglutide is deemed appropriate, your doctor will provide a prescription for the medication. It’s crucial to follow your doctor’s instructions closely when taking Semaglutide. This medication should be used in conjunction with a healthy diet and regular exercise to maximize its effectiveness. Your doctor will monitor your progress and adjust the dosage as needed to ensure safe and sustainable weight loss. Insurance Coverage and Cost Before obtaining Semaglutide for weight loss, it’s essential to check if your insurance plan covers this medication. Some insurance companies may require prior authorization or have specific criteria for coverage. If Semaglutide is not covered, you can inquire about financial assistance programs offered by the drug manufacturer or explore discount options. The cost of Semaglutide can vary depending on your insurance plan and pharmacy. It’s advisable to compare prices at different pharmacies or consider mail-order options for potential savings. Additionally, some pharmacies offer savings cards or coupons that can help reduce out-of-pocket expenses for Semaglutide. If cost is a barrier to obtaining Semaglutide, discuss this with your doctor or pharmacist. They may be able to provide guidance on affordable alternatives or assist you in navigating insurance coverage options. Remember, prioritizing your health and well-being is worth the investment in effective weight loss treatment. Monitoring and Adherence Once you start taking Semaglutide for weight loss, it’s important to stay committed to the treatment plan outlined by your healthcare provider. Regular monitoring of your weight, blood sugar levels, and overall health is crucial to track progress and address any concerns promptly. Adherence to Semaglutide therapy is key to achieving successful weight loss results. Remember to take the medication as prescribed, at the recommended dosage and frequency. If you experience any side effects or have trouble following the treatment plan, don’t hesitate to communicate with your doctor for guidance and support. Your healthcare provider may schedule follow-up appointments to assess your response to Semaglutide and make any necessary adjustments to your treatment. These check-ins are opportunities to discuss your progress, address challenges, and celebrate milestones in your weight loss journey. Potential Benefits and Risks Semaglutide has shown promising results in promoting weight loss among individuals with obesity or overweight. This medication works by reducing appetite, increasing feelings of fullness, and improving insulin sensitivity, leading to gradual and sustainable weight reduction. While Semaglutide can be an effective tool for weight loss, it’s essential to be aware of potential risks and side effects. Common side effects of this medication may include nausea, diarrhea, and gastrointestinal discomfort. Serious adverse reactions such as pancreatitis or thyroid tumors are rare but require immediate medical attention. Before starting Semaglutide for weight loss, discuss with your doctor about the benefits and risks associated with this medication. They can provide personalized guidance based on your health status and help you make an informed decision about incorporating Semaglutide into your weight loss plan. Lifestyle Modifications and Support In addition to taking Semaglutide for weight loss, adopting healthy lifestyle habits is essential for long-term success. Focus on consuming a balanced diet rich in nutrients, staying physically active, getting an adequate amount of sleep, and managing stress effectively. Seeking support from healthcare professionals, nutritionists, or support groups can also enhance your weight loss journey. Surround yourself with a positive and encouraging environment that promotes healthy choices and sustainable behaviors. Remember that weight loss is a gradual process that requires dedication and perseverance. By combining Semaglutide therapy with lifestyle modifications and ongoing support, you can achieve your weight loss goals and improve your overall health and well-being. Stay committed to your journey, listen to your body, and celebrate every small victory along the way. Overall, getting Semaglutide for weight loss involves a systematic process that begins with a consultation with a healthcare provider, navigating insurance coverage and cost considerations, monitoring adherence to treatment, understanding potential benefits and risks, and incorporating lifestyle modifications for comprehensive support. With proper guidance and dedication, Semaglutide can be a valuable tool in your weight loss journey towards a healthier and happier lifestyle. 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