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GLP-1 Weigh-In + I Wasn't Expecting This 😥 #weightlossjourney #weightlosstransformation #weightlossmotivation Hello friends and welcome back for another weekly weigh in on my GLP1 journey✨ This week has been a hard one, thank you all for watching and sending positive vibes💖 ✨If you are interested in making monetary donations to help those who have been directly impacted by the devastating Texas Hill Country flash floods here is the link💗https://www.communityfoundation.net/ 💌[email protected] ✨Follow Me On Tiktok 👇🏼 https://linktw.in/qksFEF ✨Weight Loss Playlist👇🏼 https://linktw.in/MBdDDh ⏰Time Stamps: 00:00-Intro 02:07- Weigh In 03:26- Side Effects 04:10- Rest Week Update 06:22- NSV 💿Music Cred: Music track: breeze by massobeats Source: https://freetouse.com/music Copyright Free Music for Videos

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From Trump's mastery of attention to fashion's new masculinity, exploring January's most thought-provoking cultural signals In this episode, Igor and Johannes kick off 2025 with a new monthly format exploring the media and cultural phenomena that captured their attention. They dive into two key topics that set the tone for the year ahead: First, they examine Chris Hayes and Ezra Klein's conversation about the attention economy and its implications for politics, drawing parallels between U.S. and German political landscapes. The discussion reveals how attention, rather than traditional metrics like fundraising, increasingly shapes political outcomes and cultural discourse. Second, they explore the role of curiosity and informed naivety through the lens of ERL, a Venice Beach fashion brand that offers an alternative approach to masculine aesthetics. This leads to broader reflections on meta-modernism and ways to engage with complex cultural topics beyond pure cynicism or oversimplification. The episode concludes with updates on GLP-1 medications, exploring new research about natural alternatives and emerging evidence about their effects on addiction, bringing fresh perspective to themes from previous seasons. Chapters: 00:00 - Introduction & New Format 02:14 - Attention Economy in Politics 14:45 - ERL & Meta-modernist Approaches 29:22 - GLP-1 Updates & Natural Alternatives 44:51 - Closing Thoughts Links: - Podcast episode with Ezra Klein and Chris Hayes: https://www.nytimes.com/2025/01/17/opinion/ezra-klein-podcast-chris-hayes.html - Erl Website: https://erl.store/ - Systems Magazine interview with Erl founder Eli Russel Linnetz: https://system-magazine.com/issues/issue-18/erl-eli-russell-linnetz-interview-andrew-bolton - Dr. Michael Greger on restoring our natural GLP-1 satiety circuit with fiber (video): https://nutritionfacts.org/video/a-plant-based-diet-for-weight-loss-boosting-glp-1-and-restoring-our-natural-satiety-circuit/ - OZEMPIC: Risks, Benefits, and Natural Alternatives to GLP-1 Weight-Loss Drugs (book) by Michael Greger: https://nutritionfacts.org/book/ozempic/ - Weight Loss Drugs for Curing Addiction? Podcast episode with Chris Hayes and Nicholas Reville: https://podcasts.apple.com/us/podcast/weight-loss-drugs-for-curing-addiction-with-nicholas/id1382983397?i=1000683904777 This episode marks a shift to a new monthly format where Igor and Johannes will reflect on the articles, conversations, and cultural phenomena that shaped their thinking. The discussion weaves together themes of attention economics, cultural aesthetics, and health trends while maintaining the show's focus on helping listeners update their mental models of how the world is changing. You can also listen to this episode on Apple, Spotify or wherever you get your podcasts. Follow the Rabbit on Spotify at https://podcasters.spotify.com/pod/show/follow-the-rabbit Follow the Rabbit on Apple at https://podcasts.apple.com/au/podcast/follow-the-rabbit/id1763655913 Follow the Rabbit on YouTube at https://www.youtube.com/channel/UCXKCXmFazhd1SZxoawCku0w Follow the Rabbit is a Known Unknowns production Known Unknowns on YouTube at https://www.youtube.com/@knownunknowns-xyz Known Unknowns on Instagram at https://www.instagram.com/knownunknowns.xyz/ 📧 Write to us at [email protected] Follow the Rabbit is hosted by Igor Schwarzmann & Johannes Kleske Find out more about Igor Schwarzmann at https://igorschwarzmann.com Find out moire about Johannes Kleske at https://johanneskleske.com

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Full interview: http://sigmanutrition.com/episode65/ Episode 65: Lyle McDonald is on the show to discuss the metabolic adaptations that take place when dieting, the connection between cortisol and water retention and the role of leptin in dieting and weight regain. In this episode we discuss: Metabolic adaptations to dieting Low calories + lots of cardio = no weight loss??? What’s actually going on The connection between cortisol and water retention The central role of leptin in bodyweight regulation Leptin resistance Effects of lowered calories on leptin Gender differences in hormonal responses to dieting Carbohydrate refeeds: Can they mitigate leptin drops? Which of Lyle’s books should YOU read?

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In this episode, we explore the growing popularity and science behind GLP-1 receptor agonists like semaglutide (Ozempic®, Wegovy®), medications initially developed for type 2 diabetes that have become game-changers in weight loss management. We’ll examine how these drugs work to regulate appetite, slow gastric emptying, and promote fat loss while discussing their effectiveness compared to traditional approaches. With soaring prescription rates and celebrity endorsements, GLP-1 agonists have gained attention for their transformative potential in combating obesity, a chronic condition affecting millions. Listeners will learn about the benefits, side effects, and myths surrounding these medications, as well as the economic and accessibility challenges that patients face. We’ll also highlight the importance of combining these treatments with healthy lifestyle changes to achieve sustainable weight loss. Whether you’re curious about the science or considering options for weight management, this episode delivers a comprehensive overview for the lay audience.

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Obesity is a prevalent health issue that affects millions of people worldwide. While diet and exercise are important components of weight loss, some individuals may benefit from additional medical interventions to manage their weight effectively. One such treatment that has gained attention in recent years is oral semaglutide, a medication that has shown promise in helping individuals achieve their weight loss goals.

Understanding Oral Semaglutide

Oral semaglutide is a medication that belongs to a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). These drugs work by mimicking the effects of incretin hormones, which are naturally produced in the body and help regulate blood sugar levels. In addition to managing blood sugar, GLP-1 RAs have been shown to promote weight loss by increasing feelings of fullness, slowing stomach emptying, and reducing food intake.

Unlike injectable GLP-1 RAs, which are typically administered via injections, oral semaglutide comes in a tablet form that can be taken by mouth. This convenience is appealing to many individuals who may be reluctant to use injectable medications for weight loss. However, it’s important to note that oral semaglutide should be used in conjunction with a healthy diet and exercise regimen to maximize its effectiveness.

Clinical trials have shown that oral semaglutide can lead to significant weight loss in individuals with obesity. In one study, participants who took oral semaglutide saw an average weight loss of 15% over 68 weeks, compared to a 2% weight loss in the placebo group. These results are promising and suggest that oral semaglutide may be a valuable tool in the treatment of obesity.

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There are several potential benefits of using oral semaglutide for weight loss. One of the primary advantages is its effectiveness in promoting weight loss. Studies have shown that oral semaglutide can lead to significant reductions in body weight, particularly in individuals with obesity. This weight loss can have a positive impact on overall health, reducing the risk of obesity-related conditions such as type 2 diabetes, heart disease, and stroke.

In addition to weight loss, oral semaglutide may also help improve glycemic control in individuals with diabetes. By regulating blood sugar levels, oral semaglutide can help individuals with diabetes better manage their condition and reduce the need for insulin or other medications. This dual benefit of weight loss and improved glycemic control makes oral semaglutide a valuable treatment option for individuals with obesity and diabetes.





Another potential benefit of oral semaglutide is its tolerability and ease of use. Unlike injectable GLP-1 RAs, which may cause injection site reactions or discomfort, oral semaglutide is taken orally and does not require injections. This can make it more convenient for individuals to adhere to their treatment regimen and may lead to better long-term outcomes.

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While oral semaglutide has shown promise in promoting weight loss, it is not without its limitations and considerations. One important factor to consider is the cost of the medication. Oral semaglutide may be more expensive than other weight loss medications or treatments, which can be a barrier for some individuals. It’s important to discuss the cost of oral semaglutide with your healthcare provider to determine if it is a feasible option for you.

Additionally, like all medications, oral semaglutide may cause side effects in some individuals. Common side effects of oral semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are typically mild and transient, but if they persist or worsen, it’s important to contact your healthcare provider. Your healthcare provider can help you manage any side effects and determine if oral semaglutide is the right choice for you.

It’s also important to note that oral semaglutide is not a magic solution for weight loss. While it can be effective in promoting weight loss, it should be used in conjunction with a healthy diet and regular exercise to achieve sustainable results. Making lifestyle changes and adopting healthy habits are essential components of long-term weight management, and oral semaglutide should be viewed as a tool to support these efforts.

Conclusion

Overall, oral semaglutide has shown promise as a valuable tool in the treatment of obesity and weight loss. Its ability to promote weight loss, improve glycemic control, and be well-tolerated make it an attractive option for individuals looking to manage their weight effectively. However, it’s important to consider the cost, potential side effects, and the need for lifestyle changes when deciding if oral semaglutide is right for you. By working closely with your healthcare provider, you can determine if oral semaglutide is a suitable treatment option to help you achieve your weight loss goals.

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Subscriber-only episode Resources for the Community: ___________________________________________________________________ https://linktr.ee/theplussidezpodcast Ro - Telehealth for GLP1 weight management https://ro.co/weight-loss/?utm_source=plussidez&utm_medium=partnership&utm_campaign=comms_yt&utm_content=45497&utm_term=55 ______________________________________________________________________ Part 2 In this episode, we dive deep into the real story behind obesity and type 2 diabetes, pushing past the outdated ideas of willpower and self-control. We explore how insulin resistance plays a huge role in weight gain and regain and how GLP-1 medications can help tackle these issues. Dr. Lindsay Ogle joins us to break down the science of set weight theory, explaining how our bodies are hardwired to fight weight loss, and why many people with obesity struggle to lose weight with diet and exercise alone. She gives us a better understanding of why GLP-1 medications work differently—targeting the root causes of obesity like insulin resistance—and how they help us break free from the cycle. We also take a hard look at the frustrating realities of getting access to GLP-1 treatments and discuss what other options are out there for managing hunger and preventing weight regain. But it’s not just about the science—this episode also digs into the emotional and societal factors that impact obesity. We talk about the importance of seeing obesity for what it is: a complex health condition, not a lack of discipline. Plus, we explore why, in some cases, increasing food intake can actually help people break free from cycles of disordered eating. We also get into the connection between PCOS, binge eating disorder, and Night Eating Disorder, sharing strategies on how to manage them. Ultimately, we’re all about taking a holistic approach to obesity—focusing on the whole person and finding the treatment that truly works. Info on our guests: Dr. Lindsay Ogle, MD is a board certified family & obesity medicine physician who is passionate about preventative health. Her goal is to help patients stay healthy so they may live longer and fuller lives. She recently started a telehealth clinic called Missouri Metabolic Health where she helps adults all throughout the state of Missouri treat and prevent metabolic conditions (ex: diabetes, fatty liver disease, metabolic syndrome, overweight and obesity) through lifestyle optimization and utilizations of safe and effective medications. Website: Kim Carlos, Executive Producer TikTok https://www.tiktok.com/@dmfkim?is_from_webapp=1&sender_device=pc Instagram https://www.instagram.com/dmfkimonmounjaro?igsh=aDF6dnlmbHBoYmJn&utm_source=qr Kat Carter, Associate Producer TikTok https://www.tiktok.com/@katcarter7?is_from_webapp=1&sender_device=pc Instagram https://www.instagram.com/mrskatcarter?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==

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Semaglutide, a relatively new medication on the market, has shown promising results in aiding weight loss for individuals struggling to shed excess pounds. This medication works by mimicking a hormone called glucagon-like peptide-1 (GLP-1) that is normally produced in the intestines. By activating GLP-1 receptors in the brain, semaglutide helps to reduce appetite and increase feelings of fullness, leading to lower food intake and ultimately weight loss.

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Semaglutide is a glucagon-like peptide-1 receptor agonist, which means it activates receptors in the brain that regulate appetite and food intake. By mimicking the effects of GLP-1, semaglutide helps to control blood sugar levels, reduce appetite, and promote weight loss in individuals with obesity or overweight. Studies have shown that semaglutide can lead to greater weight loss compared to diet and exercise alone, making it a valuable tool for those struggling to achieve their weight loss goals.

When taken orally once a week, semaglutide can help individuals lose weight by decreasing hunger and calorie intake. This medication has been shown to be effective in both obese individuals and those with comorbidities such as type 2 diabetes. Semaglutide works by slowing down gastric emptying, which helps to regulate blood sugar levels and reduce food cravings. Additionally, semaglutide has been shown to improve cardiovascular outcomes in individuals with obesity, making it a multifaceted treatment option for those looking to improve their overall health.

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Like any medication, semaglutide can cause side effects in some individuals. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects typically occur during the first few weeks of treatment and may subside as the body adjusts to the medication. It is important to talk to your healthcare provider if you experience persistent or severe side effects while taking semaglutide. In rare cases, semaglutide can cause more serious side effects such as pancreatitis or kidney problems, so it is essential to be monitored closely by a healthcare provider while taking this medication.





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Semaglutide may be a good option for individuals who have not been able to achieve significant weight loss through diet and exercise alone. This medication is typically prescribed for individuals with a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher with at least one weight-related comorbidity, such as type 2 diabetes or hypertension. Semaglutide is not a magic pill for weight loss, but rather a tool that can help individuals make lifestyle changes and achieve long-term success in managing their weight.

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