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After a meeting with the plastic surgeon reveals that she now weighs over 200 pounds, Jazz further pursues her weight loss journey with the help of her family. From season 7 episode 1 Subscribe to TLC Australia for more great clips: https://bit.ly/TLCAustralia Like TLC Australia on Facebook: https://www.facebook.com/TLCAU

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A recent survey by 9amHealth has revealed a significant trend in employee health benefits: employer-sponsored GLP-1 drug coverage is emerging as a pivotal factor in attracting and retaining top talent. As the competitive landscape for skilled professionals intensifies, companies are re-evaluating their health benefits packages to include innovative treatments that go beyond traditional healthcare offerings. Read more: https://xtalks.com/survey-finds-employer-sponsored-glp-1-drug-coverage-may-be-critical-for-talent-retention-and-acquisition-4115/ #shorts

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OZEMPIC Ruined Ice Spice CAREER? What happened to Ice Spice’s career—and more importantly, what happened to her iconic curves? Allegations of her reliance on Ozempic for weight loss, combined with explosive feuds, failed PR stunts, and lackluster music, have left her career on life support. Ice Spice was once on top of the world, but it seems like everything that made her famous has come back to haunt her #icespice #ozempic #centralcee Disclaimer: The content on this channel is intended for informational and entertainment purposes only. All views and opinions expressed are those of the creators and are based on publicly available information, news reports, and personal commentary. While we strive for accuracy, the information presented may not always reflect the latest updates, and we cannot guarantee its completeness or reliability. Any claims or details regarding individuals or events should be independently verified by viewers. This channel is not affiliated with, endorsed by, or in partnership with any celebrity, public figure, or organization mentioned. Images, videos, and other media used are intended under the doctrine of fair use for news reporting, commentary, and educational purposes. Please remember that commentary shared on this channel is subjective and for entertainment; it is not intended to defame, harm, or insult any individual or group. All parties are presumed innocent unless proven otherwise in a court of law. Transcript

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These drugs--Tirzepatide and Semaglutide--are not just changing the weight loss game. Every day new information is published regarding their efficacy in a wide range of chronic illnesses. They give us an exciting new tool for the management of complex illness. - The topic is GLP-1 receptor agonists (GLP-1 RAs), such as Ozempic, Wegovy, and Mounjaro (semaglutide and tirzepatide). - These drugs, originally developed for diabetes and weight loss, are being explored for broader benefits in patients with complex chronic illnesses, including long COVID and mast cell activation syndrome (MCAS). ### **Clinical Observations** - The hosts recount remarkable improvements in patients with severe, treatment-resistant symptoms (e.g., long COVID, MCAS) after starting very low doses of GLP-1 RAs. - Examples include: - A physician with disabling long COVID who, after starting a low dose of tirzepatide, regained mobility and improved overall function. - A woman with post-COVID and post-vaccine reaction, severe edema, food intolerance, and autoimmune markers, who experienced a dramatic reduction in swelling and improved food tolerance after just three injections. ### **Mechanisms & Theoretical Discussion** - GLP-1 is a natural hormone involved in insulin secretion and glucose metabolism; synthetic versions are longer-acting. - GLP-1 receptors are found throughout the body: central nervous system, muscles, immune cells (including mast cells), joints, and more. - The hosts hypothesize that the drugs’ benefits in complex illness may stem from: - Mast cell stabilization (reducing multi-system inflammation). - Modulation of immune function. - Effects on the central nervous system, possibly crossing the blood-brain barrier. - Notably, benefits are observed at microdoses (one-tenth or less of standard diabetes/weight loss doses), with minimal side effects. ### **Clinical Pearls & Practical Considerations** - Patients who are not overweight also benefit, and weight loss is minimal at these low doses. - Appetite suppression and improved food tolerance are common, leading to better quality of life. - The hosts encourage patients to re-challenge foods they previously could not tolerate after starting treatment. - There is curiosity about whether increasing the dose would yield further benefits or more side effects. - The drugs also seem to help with neurological symptoms, joint pain, and possibly even visual disturbances associated with long COVID. ### **Barriers and Logistics** - Insurance typically does not cover these drugs for off-label use, so patients rely on compounding pharmacies. - Recent FDA actions threaten the availability of compounded versions, as compounding is only allowed during official shortages. - Dosing compounded versions can be confusing, as patients must measure their own doses with insulin syringes, unlike the user-friendly commercial pens. ### **Mechanistic and Evolutionary Speculation** - The hosts discuss why GLP-1 receptors are so widespread, theorizing that modern diets and processed foods have disrupted normal physiology, and these drugs may help restore balance. - They propose that GLP-1 RAs could become important in anti-aging/longevity medicine due to their anti-inflammatory effects, similar to drugs like metformin and rapamycin. ### **Research & Future Directions** - The hosts call for more systematic data collection, including biomarkers of inflammation, to better understand and track the drugs’ effects. - They note the lack of robust clinical trial data for these off-label uses and suggest the need for case series and further research. - There is interest in comparing different GLP-1 RAs (semaglutide vs. tirzepatide) and their relative efficacy for inflammation vs. weight loss. ### **Conclusion** - The hosts are enthusiastic about the potential of GLP-1 RAs in treating complex chronic illnesses, especially given the rapid and profound improvements seen in some patients. - They plan to revisit the topic as more experience and data accumulate, and to explore combination therapy with other anti-inflammatory/anti-aging drugs like rapamycin. ## **Key Takeaways** - **GLP-1 receptor agonists, at very low doses, appear to provide significant, rapid benefits for some patients with chronic, complex illnesses (e.g., long COVID, MCAS), beyond their approved uses.** - **Benefits include reduced inflammation, improved mobility, better food tolerance, and improved neurological symptoms.** - **Mechanisms may involve mast cell stabilization, immune modulation, and central nervous system effects.** - **Access is limited by insurance and regulatory issues; compounded versions are threatened by FDA policy changes.** - **There is a need for more systematic research, including biomarker tracking and case series, to validate these observations.** - **GLP-1 RAs may have a future role in longevity and anti-aging medicine due to their anti-inflammatory properties.**

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The combined use of sodium-glucose transport protein 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists may offer notable benefits for optimizing cardiovascular and renal outcomes in patients with diabetes, according to recent research. A collaborative meta-analysis of 12 trials from the SGLT2 Inhibitor Meta-Analysis Cardio-Renal Trialists’ Consortium (SMART-C) revealed consistent positive impacts on major adverse cardiovascular events, hospitalization for heart failure or cardiovascular death, chronic kidney disease progression, and the occurrence of adverse events with the combined use of SGLT2 inhibitors and GLP-1 receptor agonists. “That information probably provides the strongest and clearest evidence yet that these drugs have independent and additive effects, and should be used in combination to further optimize cardiorenal prognosis,” Brendon Neuen, MBBS, PhD, said to HCPLive. #Diabetes #ChronicKidneyDisease #HeartFailure #Cardiology #Nephrology https://www.hcplive.com/view/brendon-neuen-mbbs-phd-optimizing-cardiorenal-prognosis--glp-1-sglt2-combination https://www.hcplive.com/view/sglt2-inhibitor-glp-1-ra-combination-improves-cardiovascular-kidney-outcomes-diabetes

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Neste vídeo, o Professor Amaury Cantilino apresenta e comenta os dados de uma pesquisa recente que discute o uso dos agonistas do receptor GLP-1 — como semaglutida, dulaglutida e tirzepatida — no manejo do ganho de peso e dos distúrbios metabólicos associados ao uso de antipsicóticos, especialmente a clozapina. Ele explica como esses medicamentos, já consolidados no tratamento da obesidade e do diabetes tipo 2, podem ser uma alternativa promissora na psiquiatria, embora ainda existam desafios, como a escassez de estudos específicos e questões relacionadas ao custo e acesso. Entenda os principais achados, as possibilidades e os cuidados necessários na aplicação dessa estratégia terapêutica em pacientes psiquiátricos. Fonte: Fink-Jensen A, Correll CU. Acta Psychiatr Scand. 2025; 151(1): 3-5. Isso e muito mais, na edição inédita e exclusiva do “Bipp Novos Papers em Psiquiatra” de hoje! Assine o bipp prime e desfrute da melhor experiência de ensino, além de benefícios exclusivos! https://bipp.sistematutor.com.br/bipp... Fique atualizado com alertas semanais por e-mail: https://acortar.link/n82HYT Assistente virtual para atendimentos presenciais e à distância? https://www.bippassistant.com.br Siga-nos no YouTube: / @bipptv Siga-nos no Instagram: / grupobipp Siga de olho na sua revista de Neurociências e Psicofarmacologia Prática (bippzine): https://qrco.de/bippzine Confira como foi o 17º episódio do bippcast! • BIPPCast 17 - "Ética e Anamnese Digital" (...

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Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today we’re diving into a topic that’s been everywhere lately: GLP-1 medications like semaglutide and tirzepatide for weight loss. You may know them by names like Wegovy, Ozempic, Mounjaro, or Zepbound. I want to give you a clear, realistic picture of what to expect—because while the media loves to highlight the dramatic before-and-after photos, the real journey can be slower and more nuanced for some. So in this episode, we’re going to talk about the truth—what these medications can do, what they can’t, how long things really take, and what you need to know to set yourself up for success. Not hype, not magic promises—just real, honest insight to help you understand the process. Let’s get into it. How GLP-1 & GIP/GLP-1 Agonists Work So first things first—how do these meds work? Semaglutide is a GLP-1 receptor agonist, and tirzepatide is a dual GIP and GLP-1 receptor agonist. Basically, they mimic natural hormones in your body that help regulate blood sugar, slow digestion, and—most importantly for weight loss—reduce appetite and improve satiety. That means you feel fuller faster and stay full longer. You're not obsessing over food like before. And that’s powerful. But—and this is a big one— these peptides don't magically erase years of weight gain overnight. What they do is help make weight loss easier by reducing hunger and supporting your metabolism—but they don't do all the work for you. It’s important to remember they're a powerful tool, not a replacement for your efforts. You're still in control of your choices, habits, and long-term success. Why We Titrate the Dose—and What "Therapeutic Dose" Means Now, let’s talk about dosing. When you start Wegovy, you don’t start at the highest dose. It’s gradually increased over several weeks to give your body time to adjust and to help reduce side effects like nausea or stomach upset. The usual schedule looks like this: You’ll start with 0.25 mg once a week for the first month. Then it increases every four weeks—0.5 mg, then 1 mg, then 1.7 mg. By week 17, most people reach the full dose of 2.4 mg once a week—that’s the dose shown in studies to lead to the most consistent weight loss, with many people losing around 15% of their total body weight over about a year. But here’s the thing—not everyone follows this path exactly, and that’s okay. Some people need to slow down or stay longer at a lower dose if they’re having side effects. Others may need to increase sooner if they’re not seeing appetite changes and are tolerating the medication well. And even though 2.4 mg is considered the “therapeutic dose,” not everyone needs to reach it. Some people feel great and lose weight at a lower dose—and if that’s you, that’s your sweet spot. The real goal is to find the lowest effective dose that controls your hunger, helps you lose weight at a steady pace, and keeps side effects to a minimum. This isn’t a one-size-fits-all journey, and pushing through side effects just to hit the max dose isn’t necessary—or safe. Your best dose is the one your body handles well and helps you make progress. *How Much Weight Can You Expect to Lose—and How Fast? Let’s take a look at the clinical studies. In large trials, people on semaglutide lost about 15% of their total body weight over 68 weeks. For tirzepatide, it was even higher—20% or more in some cases. But here’s the thing—those results happened over a year to a year and a half. Not 6 weeks. Not 3 months. It’s a marathon, not a sprint. Also, most of the weight loss doesn't happen during the titration phase. You may see some weight loss early on, especially if your appetite plummets. But the bulk of the weight loss happens once you reach and maintain your therapeutic dose. Why Everyone’s Journey Looks Different I can’t stress this enough—everybody’s journey is different. Some people feel zero hunger from their very first injection. Others don’t notice a big change until week 10 or 12. Some drop 10 pounds in the first month. Others lose two pounds and feel discouraged. All of those experiences are normal. Your age, hormones, medications, stress levels, sleep, and past diet history? They all play a role. And let’s be real—gaining 20, 50, or 100 pounds didn’t happen in a few weeks, right? It likely took months or even years of lifestyle habits, hormonal shifts, emotional eating, or underlying conditions. So we have to give ourselves that same grace and patience when we’re trying to take the weight off—even with medical support. Navigating Side...