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Please consult your doctor for medical advice. -- DISCLAIMER: This video and description contains affiliate links, which means that if you click on one of the product links, I’ll receive a small commission. This helps support the channel and allows us to continue to make videos like this. To see our full disclosure policy, please go to countessoflowcarb.com. Thank you for the support! As an Amazon Associate I earn from qualifying purchases. #mounjaro #wegovy #semaglutideKetokandies Acv Keto Gummies Reviews And Warning Watch Before BuyingStop the keto diet immediately if you notice these 9 warning signs. #health #healthy #healthittThe Rise Of Weight Loss MedicationsUltra-slow running, home exercise, sweating, burning fat, slimming the whole body, healthy livinDiet Plan To Lose Weight Fast 900 Calories Full Day Meal Plan For Weight Loss Skinny RecipesDrs Piña and Borlaug discuss the CMR substudy from the SUMMIT trial of tirzepatide in HFpEF/obesity. How does weight loss affect pericardial fat and skeletal muscle? https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt --TRANSCRIPT-- Ileana L. Piña, MD, MPH: Hello. I’m Ileana Piña, from Thomas Jefferson University in Philadelphia, Pennsylvania, and this is my blog. It’s a little bit different blog because I’m really interviewing a good friend about these glucagon-like peptide 1 (GLP-1) inhibitors. Some of our heart failure patients are getting their GLP-1 inhibitors from their primary care physicians, but many questions have arisen with the trial called SUMMIT. With us today is Barry Borlaug, who is in charge of the research section with the cardiovascular section of Mayo, and that is Mayo, Rochester, where it must be much colder even than here in Philadelphia. Barry, congratulations on that trial. Tell our audience a little bit about how the trial was structured because it’s important how we get into your information. SUMMIT Recap Barry A. Borlaug, MD: Thanks, Ileana. SUMMIT was a randomized, double-blind, placebo-controlled trial, testing the GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Unlike some other trials, this was real HFpEF with an ejection fraction of 50% or above. Patients were randomized 1:1 to tirzepatide, titrated up to 15 mg once weekly, or placebo and treated for a minimum of 52 weeks. The dual primary endpoints were worsening heart failure or cardiovascular death and quality of life by the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. The median duration of follow-up was 2 years. We continued follow-up until the last patient enrolled completed the full 52-week period of treatment. We found that, as compared to placebo, tirzepatide reduced the risk of worsening heart failure or cardiovascular death by 38%, which was statistically significant, and also improved the KCCQ clinical summary score. In addition to that, we also looked at other patient-centered outcomes like 6-minute walk distance and biochemical markers like C-reactive protein (CRP). We saw that there was also a significant improvement in exercise function measured by 6-minute walk distance and about a 40% decrease in CRP levels. Piña: How long did the total trial last, including the time that the drugs were being administered? Borlaug: The longest duration of follow-up was 3 years, and the median follow-up was 2 years. Piña: Were any of these patients also on sodium-glucose cotransporter 2 ( SGLT2) inhibitors ? Borlaug: Yeah, a minority of patients were also on SGLT2 inhibitors, about 17%. Piña: What was the baseline KCCQ score? Borlaug: Very poor. A s you know, physician-reported heart failure severity often doesn’t agree with patient reports. Overall, 72% of the patients were judged by their physicians to have class II heart failure, but the mean KCCQ score was just over 53, so pretty severe patient-reported limitations or severe HFpEF. Despite this — and this is often the case in HFpEF and obesity-related HFpEF — the median N-terminal pro-B-type natriuretic peptide ( NT-proBNP) was only 175. Piña: I was very surprised at that. Very surprised. That really is low. That was NT-proBNP. That wasn’t BNP. 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The content is offered on an informational basis only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified health provider before making any adjustment to a medication or treatment you are currently using, and/or starting any new medication or treatment. All recommendations are “generally informational” and not specifically applicable to any individual’s medical problems, concerns, and/or needs.Weight Loss Prescription Pills Review Do Watch Weight Loss Prescription Pill Reviews WeightlossWant to know why you're not getting the weight loss results you want? The secret is creating...Hepatoburn Link Below Guthealth Liver Weightloss Fatburner Burn Fat Gummies ExploreJoin us for a powerful conversation with Dr. Dean Jones DC, a leading holistic obesity expert and functional medicine doctor, as he dives into the world of GLP-1 weight loss peptides like semaglutide and tirzepatide! 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As with any exercise program, if at any point during your workout you begin to feel faint, dizzy, or have physical discomfort, you should stop immediately and consult a medical professional. COPYRIGHT NOTICE This video is protected by International copyright laws. Reproduction and distribution of the video without the creator's written permission are strictly prohibited. Any illegal reproduction of this content will result in immediate action against the person concerned.Assessing The Impact Of Keto Xps Appearance On Shark TankLive Streaming : https://v7.video/livestreaming/TRANS7-Live-Streaming === FYP (FOR YOUR PAGI) Senin, 27 Februari 2023 PART 1 : https://youtu.be/mZ7RlX7mm6Q PART 2 : https://youtu.be/ert1bAu90qQ PART 3 : https://youtu.be/J_dzDmL8Mhg PART 4 : https://youtu.be/5Ee2Prut_GE PART 5 : https://youtu.be/C4dDHmXPSDA ============= "FYP: FOR YOUR PAGI" TAYANG SETIAP HARI SENIN - JUMAT PUKUL 08.30 WIB ================ #FYP #FYPTRANS7Bellyfatloss Fatloss Weightloss FitnessmotivationGLP-1 benefits BEYOND weight loss #weightloss #glp1 #healthylifestyle #fatlosstips #insulinresistance #glp1journey #obesity #obesitymedicine #LIVEhighlights #TikTokLIVE #LIVETransform Your Diet With Go Keto GummiesIt’s one of the most common questions we get — and the answer isn’t black and white. 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Check out our Amazing Superfoods: https://bit.ly/2JAan8p Follow us on Facebook: https://www.facebook.com/Organifi/ Instagram: https://www.instagram.com/organifi/ Pinterest: https://www.pinterest.com/juicing/ Twitter: https://twitter.com/organifi Check out our blogs: http://fitlife.tv/ https://www.organifishop.com/blogs/news Join the Organifi Tribe: https://www.organifishop.com/pages/join-our-tribe Get my free Alpha Reset Guide Here: http://www.organifi.com/ytalpha/ things that stall fat loss, ways to avoid undermining your fat loss, things that could be stalling your fat-loss progress, tips on how to break weight loss plateau, ways to break weight loss plateau, weight loss stalls and plateaus, overlooked problems that sabotage fat loss, when weight loss stalls, reasons you are not losing weight, managing a weight loss plateau BodyBuilding.com, Lean Bodies Consulting, Built Lean, Reveal the Steel, FitlifeTVRapid Keto Acv Gummies Reviews Side Effects Best Results Works BuyFor Personalized Diet Plans: Email - [email protected] -------------------- Subscribe to This Channel: https://www.youtube.com/@FattoFabSuman Subscribe to My Vlog Channel: https://www.youtube.com/@sumansunshinesecrets ========== Follow Us On ========== Facebook - https://www.facebook.com/FattoFabSuman Instagram - https://www.instagram.com/suman_sunshine Twitter - https://twitter.com/FattoFabSuman LinkedIn - https://www.linkedin.com/company/fat-to-fab/ Website - https://sumanpahuja.com/ #fattofab Disclaimer: There is no guarantee of specific results and the results can vary from person to person. 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