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Dr Luis Otávio Caboclo, neurologista formado no Hospital das Clinicas da FMUSP, mestrado e doutorado pela Universidade de São Paulo, professor da Faculdade de Medicina Hospital Albert Einstein. Dr Marcelo De Lima Oliveira doutor pelo departamento de neurologia do Hospital das Clinicas da Faculdade de Medicina da USP Dr Luis Otavio Caboclo nesse podcast detalha as formas da planta Cannabis: para uso recreativo a planta tem altas concentrações de THC (cannabis sativa) e para uso medicinal a planta tem altas concentrações de CBD (canabbis sativa com muito canabidióde) e baixas concentrações de THC conhecida como cânhamo. Existem mais de 120 substancias (terrenos e flavonóides, entre outros) na planta cannabis sendo as duas principais CBD e THC. A cannabis é estudada há mais de 2000 mil anos antes de Cristo para tratar certas condições clinicas na China. Em Bagdá (Mesopotâmia) no século VII um médico usou a Canabbis para fins medicinas. No século XIX um médico inglês usou a Cannabis Índica na Índia para tratar uma forma de epilepsia grave (síndrome de West). Esse médico levou esse conhecimento para o Reino Unido que incluiu a Cannabis na farmacopéia britânica e nessa corrente também foi incluída na farmacopéia americana. Porém, na década de 40 percebeu-se os efeitos psicotrópicos da Cannabis com alto teor de THC e dessa forma, o governo americano proibiu o uso de Cannabis para qualquer forma de uso e consequente interrupção das pesquisas. Na década de 60 em Israel, Raphael Mechoulam iniciou novamente as pesquisas com Cannabis a partir de uma porção de maconha apreendida pela polícia. Este cientista foi o primeiro a identificar as moléculas CBD e THC. Na década de 70 professor Elisaudo Carlini publicou um periódico com tratamento de crises epiléticas com CBD em animais sem efeitos no comportamento deles. Mais tarde esse mesmo professor publicou um artigo com 6 pacientes que foram tratados com ótimos resultados com CBD. Na década de 90 identificou-se o sistema endocanabidióide onde achou-se receptores para o CBD em varias partes do corpo humano (pele, olhos, sistema gastrointeistal, etc..) inclusive no cérebro que são os principais alvos de CBD. As principais medicações com Cannabis sativa: 1) CBD isolado e purificado, sem THC, 2) Extrato integral da planta com CBD, THC e flavonóides e no Brasil a concentração de THC é de 0,2%, 3) Extrato integral sem THC, 4) CDB com THC com concentração mais alta de THC. Na pratica clinica é mais utilizada CBD isolado e Extrato integral de Canbbis. Efeito Entourage é o efeito que quando todas as substancias da Cannabis atuam juntas elas melhoram os efeitos do CBD. Principais indicações: Eplepsias refratárias (síndromes de Dravet, West, Lenox Gastaut, entre outras), dor crônica, espasticidade em pacientes com esclerose múltipla e caquexia com anorexia em pacientes com AIDS. Estas indicações tem nível de evidencia forte. Ainda com níveis de evidencias baixos: Autismo, controle comportamental de pacientes com Alzheimer, entre outros. Acesso no Brasil: desde 2014 a Cannabis foi liberada para uso medicinal no Brasil. A primeira forma de acesso foi a importação direta para pessoas que precisam da medicação, porém este processo é demorado e trabalhoso. Recentemente as farmácias foram autorizadas a importar as medicações o que facilitou o acesso à Cannabis. Algumas ONGS conseguiram autorizações liminares para plantar Cannabis no Brasil e extrair o óleo da planta e fornecer para pessoa de baixo poder aquisitivo, pois o produto na farmácia tem alto custo; atualmente estado de SP vai fornecer a medicação custeada pelo SUS. Há famílias que tem autorização judicial para plantar a Cannabis para consumo próprio do CBD. #cannabis #CBD #sistemaendocanabiode #eplepsia #dor #alzheimer #THC

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CBD ist im Trend. Dutzende Influencer preisen CBD-Öl und andere Produkte als Wundermittel an, das ihr Leben leichter macht. Aber stimmen die ganzen Behauptungen? Die Science Cops denken sich: Studieren geht über Probieren. CBD-Öl soll der Gamechanger sein: Schlafstörungen, Angststörungen, Depressionen, Augeninnendruck und Tumore oder generell Schmerzen, all das soll CBD-Öl heilen oder mindern. Und bei einer derartigen Litanei an Gesundheitsversprechen haben die Quarks Science Cops, Jonathan Focke und Maximilian Doeckel, generell Fragen. Die sie aber auch ihrer Chefin Andy (Aysha Samuel) erklären müssen, denn die ist selbst fleißige Nutzerin von CBD. Aber als sie ihre Fragen stellen, schicken die Hersteller selbst den beiden einen großen Stapel Studien, welche die Wirksamkeit von CBD belegen sollen. Und tatsächlich scheint eine gewisse Wirksamkeit belegbar. Also doch alles gut? Nicht nur die Science Cops, sogar ihr Koch Ralph (Ralph Caspers) wird argwöhnisch und glaubt, die Studien der CBD-Hersteller vernebeln eine unangenehme Wahrheit. Kapitel: 00:00: Intro 01:26: CBD, das Wundermittel der Influencerinnen und Influencer 02:30: Die Versprechen von CBD 04:38: Die Wirkweise von CBD 06:35: Der Fall Charlotte Figi 08:05: Die "Studien" der Hersteller 13:04: Die Studie, bei der CBD gewinnt 15:02: Warum CBD überteuerter Unsinn ist Quellen (Auswahl, volle Liste unter https://www.quarks.de/podcast/quarks-science-cops-allheilmittel-cbd/): "CBD-Öl legal auf dem Markt? (Verbraucherzentrale 2021) https://www.verbraucherzentrale.de/wissen/lebensmittel/nahrungsergaenzungsmittel/cbdoel-legal-auf-dem-markt-37660 Cannabis: Potenzial und Risiko: Eine wissenschaftliche Bestandsaufnahme herausgegeben von Eva Hoch, Chris Maria Friemel, Miriam Schneider (Springer Medizin, 2019) https://link.springer.com/book/10.1007/978-3-662-57291-7 McPartland, J. et al.: Are cannabidiol and Δ9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review (BJP 2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301686/ Di Marzo, V. et al.: Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action (National Library of Medicine 1999) https://pubmed.ncbi.nlm.nih.gov/9881850/ Blessing, E. et al.: Cannabidiol as a Potential Treatment for Anxiety Disorders (Neurotherapeutics 2015) (PDF) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/pdf/13311_2015_Article_387.pdf Mol Sci, Int: The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and Targets (PMC 2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124847/ Suraev, A. et al.: Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) for chronic insomnia disorder (‘CANSLEEP’ trial): protocol for a randomised, placebo-controlled, double-blinded, proof-of-concept trial (BMJ 2020) https://bmjopen.bmj.com/content/10/5/e034421 Epidyolex (European Medicines Agency) https://www.ema.europa.eu/en/medicines/human/EPAR/epidyolex Graczyk, M. et al.: Prospects for the Use of Cannabinoids in Psychiatric Disorders (Front Psychiatry 2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994770/ Masataka, N.: Anxiolytic Effects of Repeated Cannabidiol Treatment in Teenagers With Social Anxiety Disorders (Front Psychol. 2010) https://www.frontiersin.org/articles/10.3389/fpsyg.2019.02466/full Antonio, Z.: Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life (Front Pharmacol 2017) https://www.frontiersin.org/articles/10.3389/fphar.2017.00259/full Lopez, H.: Effects of Hemp Extract on Markers of Wellness, Stress Resilience, Recovery and Clinical Biomarkers of Safety in Overweight, But Otherwise Healthy Subjects (Journal of Dietary Supplements 2020) https://www.tandfonline.com/doi/abs/10.1080/19390211.2020.1765941?journalCode=ijds20 Shannon, S. et al.: Cannabidiol in Anxiety and Sleep: A Large Case Series (The Permanente Journal 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/?report=reader Das, R. et al.: Cannabidiol enhances consolidation of explicit fear extinction in humans (Psychopharmacology 2013) https://link.springer.com/article/10.1007/s00213-012-2955-y Medikamente auf Cannabis‐Basis zur Behandlung chronischer neuropathischer Schmerzen bei Erwachsenen – Mücke, M – 2018 (Cochrane Review 2018) https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012182.pub2/full/de Notcutt, W. et al: Initial experiences with medicinal extracts of cannabis for chronic pain: Results from 34 ‘N of 1’ studies (Association of Anaesthetists 2004) https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2044.2004.03674.x?sid=nlm%3Apubmed Ewing, L. et al: Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model (Molecules 2019) https://www.mdpi.com/1420-3049/24/9/1694 #cbd #cbdforlife #cbdöl #quarkssciencecops #sciencecops

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The Good Morning Mix from HelloMOOD was very different than the last batch we tried. But this was ANOTHER Interesting night for sure! We recorded the entire experience again. These gummies have THCV in them. But what is THCV? "What is THCV? Tetrahydrocannabivarin, or THCV, is a psychoactive cannabinoid found most prevalently in Sativa strains of cannabis. It is known to produce a more motivated, alert and energizing feeling of euphoria. For this reason, it is often recommended for daytime or any time when functionality is important." Dave's back pain VANISHED completely. And this particular Morning Mix gummy did not knock Dave on his butt! I.E. He did not fall asleep at hour 3.5 like last time. So that was REALLY nice. The giggles and perma-grin were both in full-effect with these new gummies too, though the giggles came later than before. And the munchies were back with a vengeance. The pain relief was the most noticeable effect (For Dave). Like before, one minute his back hurt, the next it didn't! So that was REALLY nice. We consider this the most IMPORTANT effect. Everything else is nice, but the pain relief was VERY NICE. Dave decided to try Hello MOOD Morning Gummies and their Delta 9 THC & CBD Gummies! These are totally legal where we live, but as with anything - do your own research and homework! These are just our opinions, not advice of any sort, and you should always do your due diligence when trying something new! THIS IS NOT A PAID ADVERTISEMENT! We received nothing for making this video - outside of our own hilarity. ;) That being said - it was FUN for sure! :) The Morning Mix Gummies We Tried From HelloMood! https://hellomood.co/product/morning-delta-9-thc-gummies/ About Hello MOOD: https://hellomood.co/about-mood/ Dave's REAL Job when he's not having fun with "adult" gummies: https://www.davidshockleyauthor.com #hellomood #delta9thc #delta9gummies

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Discover why we're Google's top result! We're sharing an example of CBD gummies for sleep, answering almost every question in our detailed overview. Learn how we dominate the search results for your CBD sleep needs! #CBDGummies #SleepAids #CBDForSleep #GoogleRankings #SEO #OnlineMarketing #TopResult #CBDHealth #Wellness #SleepWell