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THC and CBD are easily the two most common cannabinoids we hear about and see in the industry then and now/today They are both produced by the cannabis plant, in the glandular trichomes of the unfertilized female flower, in their acidic forms! so actually they are termed phyto-cannabinoids, whereas endocannabinoids are the cannabinoid-like molecules we produce endogenously that interact with our endocannabinoid system lets take a look at THCs and CBDs structure they contain the same # of Carbon, oxygen, and hydrogen atoms, (C21H30O2) their mass is the same at 314 grams per mol they almoooostt look identical, However, there is one tiny difference, THC contains an ether which created a cyclical ring, whereas THC has a hydroxyl group Oddly enough this is the difference between getting high and not getting high lol And this is likely why CBD has a broader spectrum of pharmacological effects than THC its More like a tiny big difference, knawimsayin so, like we kinda hinted to, THC is the main intoxicating psychoactive component of cannabis It has this effect on us because it binds to our CB1 receptors, its what’s known as a weak partial agonist on the otherhand, although CBD is psychoactive, its NON INTOXICATING – its psychoactive because it interacts with and modulates our nervous system and yes, it ALSO interacts with the CB1 receptors, but in a different way from THC CBD binds to another area on the receptor, which causes the receptors to release THC. CBD is what’s known as a Negative allosteric modulator on CB1 CBD interacts with a variety of other receptors in our body too, which will be in that video Combining CBD and THC decreases the psychoactivity and other side effects of THC, while enhancing some of THC’s benefits. And when you get the CBD to THC ratio to be about a 1:1, or higher on the CBD side it’s a great way to use cannabis for relief without having to worry about getting high I hope you learned something and ill see ya next time!Police 3 Girls Get High From Cannabis Gummies At Mcmonagle SchoolHigh Ties is a local and independently owned cannabis retail company. We provide a safe shopping environment featuring state of the art technology and knowledgeable bud experts. Our friendly subject matter experts are trained to answer your burning questions and share their understanding, and passion for cannabis with you. 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The best CBD vape pens are: 1:13 - Wenax K1 02:56 - Caliburn G 04:04 - Smok Acro Pod 05:44 - Vaptio Airgo 08:08 - Vaporesso Orca Solo 09:42 - Innokin T22 ProSavage CBD Reviews: 6 High-Potency Oils & Edibles for Serious Wellness SeekersThis video is about TKO The Terp Nation CBD Moon Rocks Review. Check them out @ www.theterpnation.comCheef Botanicals CBD Gummy Cubes: A Comprehensive ReviewThe Science behind Marijuana (Cannabis), Marijuana mechanism of action. Source of information: National Institute on Drug Abuse; National Institutes of Health; U.S. Department of Health and Human Services. Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images. Voice by: Sue Stern Animation ©Alila Medical Media. All rights reserved. Marijuana, also known as cannabis, among other names, is a preparation of the Cannabis sativa plant - the hemp plant, intended for recreational and medicinal uses. The main psychoactive chemical in marijuana is delta-9-tetrahydro-cannabinol, or THC. The Cannabis plant preparation also contains other compounds that are chemically related to THC, called cannabinoids. THC is chemically similar to a class of substances found naturally in our nervous system called endogenous cannabinoids, or endocannabinoids, of which anandamide is best known so far. The endocannabinoids are part of a newly discovered system named the Endocannabinoid system, or ECS. How the ECS works The ECS acts as a modulator of neurotransmission. When the postsynaptic neuron is activated, endocannabinoids are produced, released, and travel back to the presynaptic neuron where they activate cannabinoid receptors. By doing so, they control what happens next when the presynaptic cell is again stimulated. The general effect is a decrease in the release of neurotransmitters such as GABA or glutamate. In other words, the ECS acts as a “brake”, slowing down neuronal activities, preventing neurons from excessive firing. Some examples of ECS functions include: - Pain modulation: cannabinoids suppress pain signal processing, producing pain relief effects. - Stress and anxiety reduction: The ECS has been implicated in the habituation the body’s response to repeated exposure to restraint stress. - Mood regulation: the ECS promotes “good feeling” by inducing dopamine release in the brain reward pathway. This explains the euphoria, or the “high”, experienced by marijuana users. THC mode of action is however different from other drugs: it induces dopamine release INDIRECTLY by removing inhibitory action of GABA on dopaminergic neurons. The ECS is also involved in many more bodily activities, including appetite, memory, learning, sleeping patterns, immune functions and fertility. So how can marijuana be harmful if it does exactly what our body already does to itself? The endocannabinoids are short-acting transmitter substances. They are synthesized on demand and their signaling is rapidly terminated by specific enzymes. Marijuana users consume a much higher amount of THC. THC is also much more stable and can persist in the body for a longer period of time. THC overwhelms the EC system, overriding normal brain functions. Because cannabinoid receptors are present in many parts of the brain and body, the effects of THC are wide-ranging. It can slow down a person’s reaction time, which could impair driving or athletic skills; disrupt short-term memory and higher thought processes, which could affect learning capabilities and judgment ability. Higher doses of THC may also lead to reverse effects. Consuming marijuana by smoking may also damage the lungs to a similar extent as smoking cigarettes. Long - term effects of THC Substantial evidence from animal research indicates that marijuana exposure can cause long-term adverse changes in the brain. Long-term effects of marijuana in human are still debatable mostly due to difficulties of conducting research in human beings. Medical uses of marijuana While recreational use of marijuana is without doubt harmful, the Cannabis plant may be a valuable source of medicines. Currently, the two main cannabinoids from the marijuana plant that are of medical interest are THC and cannabidiol, or CBD. These chemicals are used to increase appetite and reduce nausea in patients undergoing cancer chemotherapy. They may also be useful in reducing pain and inflammation, controlling epileptic seizures, and possibly even treating autoimmune diseases and cancers.