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CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis), CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system. In this video, I discuss what we know about CBD’s mechanism of action and its potential in treating various conditions like epilepsy and anxiety. TRANSCRIPT: CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis) CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system, which may enable it to modulate the effects of thc as well as have actions of its own. CBD is chemically similar to THC, but it does not have the same mechanism of action, and some evidence suggests it may even interfere with some of the actions of THC. One way it may do this is by binding to receptors that THC binds to known as CB1 receptors, but instead of activating them, causing a change in the receptor that reduces THC’s ability to interact with it. This type of effect is known as negative allosteric modulation, and it may enable CBD to mitigate some of the adverse effects of THC, like anxiety. Other research, however, suggests CBD can enhance certain effects of THC, and CBD is also thought to act at a number of other targets besides the CB1 receptor. For example, CBD is believed to activate serotonin receptors and may increase levels of a natural cannabinoid called anandamide by blocking anandamide reuptake and inhibiting the enzymatic breakdown of anandamide. Overall, although a number of targets for CBD have been identified, its mechanism of action is still poorly understood. CBD is generally well-tolerated, but some have raised concerns about the need for more research before we can be confident about its safety in all populations. CBD, however, is not thought to have potential for abuse, and some believe it does have potential for treating a number of conditions, like anxiety, insomnia, and pain. But most of these claims don’t yet have strong evidence to support them, and more research is needed, although CBD has been found to be a viable treatment for at least some types of epilepsy. REFERENCES: Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 2015;172(20):4790-4805. doi:10.1111/bph.13250 McPartland JM, Duncan M, Di Marzo V, Pertwee RG. Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol. 2015;172(3):737-753. doi:10.1111/bph.12944 Pisanti S, Malfitano AM, Ciaglia E, et al. Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther. 2017;175:133-150. doi:10.1016/j.pharmthera.2017.02.041 World Health Organization (WHO). Cannabidiol (CBD): Pre-Review Report. November 2017. Accessed June 28, 2020. https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf Special thanks to Srikar Gade for help with fact-checking this video.

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Delta 8 THC has exploded in the hemp industry with a lot of hype and controversy behind it. This psychoactive cannabinoid is in a legal grey area that allows for hemp processors to create a product similar to delta 9 THC without the legal ramifications of producing delta 9 outside of legal jurisdiction. Though less potent than its delta 9 sibling, delta 8 is less potent. Nonetheless, it is a psychoactive cannabinoid that does produce a "high" when used. For this reason, there is a lot of interest, and a lot of skepticism, surrounding this hemp compound. In this episode of extrakTALKS, Dr. Jon and Randall Thompson dive into the fascinating topic of delta 8 THC. They will detail a number of important factors including how delta 8 is made, the legal status of delta 8, the differences and similarities from delta 9, delta 8 and other hemp cannabinoids and much more. To learn more, visit our website: http://www.extraktlab.com We have tons of useful information in our No Holds Barred playlist https://www.youtube.com/playlist?list=PLQX9clbTgskpmjbiHCtAY9Y_zti3hvrtH Are you stuck in your business, need a solution? Schedule a free jam Session to get you the solution you need: https://extraktlab.com/jamsession/ Visit our blog for other important resources at https://extraktlab.com/blogDownload our Distillation Guide to learn the ins and outs of all things distillation: https://extraktlab.com/wiped-film-distillation-guide/ Watch as Dr. Jon gives a Live Tour of 5 Ton/Day Hemp Processing Facility: https://extraktlab.com/live-tour Here is a link to a FREE Advanced guide to extraction: https://extraktlab.com/advanced-extraction-guide/ Have a recommendation for a future Q+A? Leave a suggestion in a comment below! Social handles: Instagram: instagram.com/extrakt_lab Twitter: twitter.com/ExtraktLAB Facebook: facebook.com/extraktlab LinkedIn: linkedin.com/company/ExtraktLAB YouTube: youtube.com/c/ExtraktLAB Timestamps: 0:00 Introductions 3:55 Does Delta 8 come from the hemp plant? 5:56 What is the difference between Delta 8, Delta 9 and Delta 10? 6:30 The Entourage Effect 8:10 Molecular structure of D8, D9 and D10 12:30 Comparing potency, effects and safety, legality and availability of D8, D9 and CBD 14:30 Formulation possibilities 15:00 Ratios of Delta 8 and other cannabinoids in formulations 17:00 Various ways in which cannabinoids are metabolized 18:05 The legal implications of delta 8 19:45 Delta 9 in Delta 8 products after conversion 20:45 Legality of Delta 9, Delta 8 and CBD 22:15 Availability of Delta 9, Delta 8 and CBD 24:50 The rise of Delta 8 demand 25:13 How extraktLAB can help you with your extraction business

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