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So, let’s take a look at some of the most recent research in order to shed some light on the mechanism for how CBD affects the principal cannabinoid receptor in the brain, the CB1 receptor. This is a major discovery that gives further insight into how CBD has been shown to have an effect upon symptoms of conditions such as epilepsy, depression, and other neurological disorders. I’ll also be explaining the different psychoactive effects produced by the two most studied cannabinoids. Now, if you’re like most people, you’ll recognize them as THC and CBD. Compared with THC, CBD shows a more defined anticonvulsant profile and is largely devoid of adverse intoxicating or psychotropic effects. However, THC plays a major role in the entourage effect when combined in trace amounts with the other cannabinoids which can all be found naturally in the hemp variety of cannabis. The interest in cannabis-based products for the treatment of refractory or unmanageable epilepsy has skyrocketed in recent years as it relates primarily to CBD and its ability to treat this difficult condition in children as well as adults. Initial theory pointed to the fact that CBD does not affect the cannabinoid receptors of the brain however the latest research out of Canada shows that CBD is a negative allosteric modulator of the cannabinoid receptor 1 (CB1). This is the same receptor found within the central nervous system (CNS) that is responsible for THC’s intoxicating or psychotropic high. So, what I’m actually saying is that CBD is able to bind to the CB1 receptor, contrary to previous scientific thought, at a different location than where THC does. When THC binds to a CB1 receptor on the outside of a neuron, the receptor relays certain instructional signals to the inside of the cell. If CBD binds to the CB1 receptor at the same time THC is present, the neuron receives a diminished or dampened signal. The two substances in combination act synergistically at the CB1 receptor creating an obvious effect that is distinct from that of THC alone. Scientists already suspected that CBD must act in some way on the CB1 receptor which infringes on THC’s action at the same CB1 receptor. In addition to its interaction with the CB1 receptor, CBD's other medicinal effects stem from completely separate pathways, as in the cannabinoid receptor 2 (CB2), such as the mu- and delta- opioid receptors. Taken on its own, CBD has sedative, anxiolytic (anti-anxiety) and anti-depressant effects on the brain, but does not create the overtly psychotropic high like THC will alone. This new discovery represents another important step forward into understanding the effects of both CBD and THC on the brain. Further research like this will aid doctors and caregivers in choosing the best protocol for patients with different needs. So, contrary to popular and previous scientific beliefs, these studies have shown that CBD does have an effect upon the CNS’s CB1 receptor. This simply opens the door for further investigation into the many potential effects CBD truly has upon the brain as well as the rest of the nervous system. *This content is strictly the opinion of Dr. Barry Morrison and is for informational and educational purposes only. It is not intended to treat, cure, prevent, provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Barry nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. 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