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This video was created by Demystifying Medicine students Simran Matharu, Mahek Minhas and Micaela McNulty in collaboration with the McMaster Demystifying Medicine Program Copyright McMaster University 2021 For more information visit: https://www150.statcan.gc.ca/n1/pub/82-003-x/2014011/article/14112-eng.htm Time Stamps: Introduction/What is Parkinson’s Disease? → 00:00 - 01:23 What is Cannabis? → 01:24 - 02:34 How Can Cannabis Help With Parkinson’s? → 02:35 - 05:09 Physician Perspectives → 05:10 - 07:19 Conclusion → 07:20 - 07:52 References: Bega, D., Simuni, T., Okun, M. S., Chen, X., & Schmidt, P. (2016). Medicinal cannabis for Parkinson's disease: Practices, beliefs, and attitudes among providers at national Parkinson Foundation centers of excellence. Movement Disorders Clinical Practice, 4(1), 90-95. Benner, E. J., Banerjee, R., Reynolds, A. D., Sherman, S., Pisarev, V. M., Tsiperson, V., Nemachek, C., Ciborowski, P., Przedborski, S., Mosley, R. L., & Gendelman, H. E. (2008). Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PloS one, 3(1), e1376. Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2009). The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology, 56, 235–243. de Lau, L. M., & Breteler, M. M. (2006). Epidemiology of Parkinson’s disease. The Lancet Neurology, 5(6), 525–535. Edelstein, O. E., Wacht, O., Isralowitz, R., Reznik, A., & Bachner, Y. G. (2020). Beliefs and attitudes of graduate gerontology students about medical marijuana use for Alzheimer’s and Parkinson’s disease. Complementary Therapies in Medicine, 52, 102418. Gardiner, K. M., Singleton, J. A., Sheridan, J., Kyle, G. J., & Nissen, L. M. (2019). Health professional beliefs, knowledge, and concerns surrounding medicinal cannabis – A systematic review. PLOS ONE, 14(5), e0216556. Hauser, R. A., Rascol, O., Korczyn, A. D., Jon Stoessl, A., Watts, R. L., Poewe, W., De Deyn, P. P., & Lang, A. E. (2007). Ten-year follow-up of Parkinson's disease patients randomized to initial therapy with ropinirole or levodopa. Movement disorders: official journal of the Movement Disorder Society, 22(16), 2409–2417. Jankovic, J. (2008). Parkinson’s disease: Clinical features and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry, 79(4), 368–376. Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L. E., Huang, X.-F., Liu, K., Arnold, J. C., & McGregor, I. S. (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443–457. Lang, A. E., & Lozano, A. M. (1998). Parkinson’s Disease. New England Journal of Medicine, 339(16), 1130–1143. Laun, A. S., & Song, Z. H. (2017). GPR3 and GPR6, novel molecular targets for cannabidiol. Biochemical and biophysical research communications, 490(1), 17–21. Marras, C., Beck, J. C., Bower, J. H., Roberts, E., Ritz, B., Ross, G. W., Abbott, R. D., Savica, R., Van Den Eeden, S. K., Willis, A. W., & Tanner, C. (2018). Prevalence of Parkinson’s disease across North America. Npj Parkinson’s Disease, 4(1), 21. Nutt J. G. (2000). Response to L-dopa in PD: the long and the short of it. Neurology, 54(10), 1884–1885. https://doi.org/10.1212/wnl.54.10.1884 Oeckl, P., Hengerer, B., & Ferger, B. (2014). G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology, 257, 1–9. https://doi.org/10.1016/j.expneurol.2014.04.010 Severe Spasticity. (2020). https://lioresal.com/severe-spasticity/. Venderová, K., Růzicka, E., Vorísek, V., & Visnovský, P. (2004). Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms. Movement disorders: official journal of the Movement Disorder Society, 19(9), 1102–1106. https://doi.org/10.1002/mds.20111 Wang, M., Wang, Y.-H., Avula, B., Radwan, M. M., Wanas, A. S., Mehmedic, Z., van Antwerp, J., ElSohly, M. A., & Khan, I. A. (2017). Quantitative Determination of Cannabinoids in Cannabis and Cannabis Products Using Ultra-High-Performance Supercritical Fluid Chromatography and Diode Array/Mass Spectrometric Detection. Journal of Forensic Sciences, 62(3), 602–611. https://doi.org/10.1111/1556-4029.13341Understanding the Side Effects of CBD Oil: A Comprehensive OverviewJustbob presenta uno dei suoi prodotto più nuovi e con il più alto contenuto di CBD perché ricoperta da cristalli di CBD e da una abbondante spolverata di hashish. Quando il cliente si trova davanti queste meravigliose perle, quasi gli sembra di stare facendo alpinismo, proprio perché sembrano essere le versioni contenute di rocce dolomitiche ricoperte da soffice neve. 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Conversely, CBD interacts more subtly with cannabinoid receptors, exhibiting a range of effects that do not include the intoxicating “high” associated with THC. This quality has made CBD especially popular in wellness products, and it is often chosen by individuals seeking relief from anxiety, inflammation, or chronic pain without the side effects associated with THC. The legal status of THC and CBD also varies widely across different regions and countries around the world. In some places, THC is heavily regulated due to its psychoactive nature, while CBD products remain more accessible as long as they contain minimal traces of THC. This mixed legality means that consumers must remain aware of their local laws regarding cannabis use and possession. Additionally, much attention is being paid to the benefits of both THC and CBD as more research emerges into the entourage effect, which suggests that these cannabinoids may work better in tandem than in isolation. Understanding these nuances will empower consumers to make informed decisions regarding their cannabis use, whether for recreational enjoyment or potential therapeutic benefits. Psychoactivity and Effects on the Body The primary distinction between THC and CBD lies in their psychoactive properties. THC is well known for its ability to induce a state of euphoria, commonly referred to as the “high.” This phenomenon occurs due to THC’s affinity for CB1 receptors in the brain, resulting in alterations in mood, perception, and cognition. For many recreational users, this intoxicating effect is the primary goal; however, it may not be suitable for everyone, particularly those who experience anxiety or paranoia as a result of THC consumption. In contrast, CBD offers a different experience altogether. It is non-psychoactive and does not produce the high associated with THC. Instead, many users report feelings of relaxation and stress relief without the mind-altering effects. This distinction makes CBD particularly appealing for those seeking the potential benefits of cannabis without the side effects often linked to THC. Moreover, recent studies have indicated that CBD may also counteract some of the more intense psychoactive effects of THC, making it a valuable inclusion in formulations that combine both cannabinoids. Understanding the psychoactive properties of THC and the non-intoxicating nature of CBD is crucial for consumers. For instance, individuals who might be sensitive to psychoactive effects may opt for CBD products exclusively, while others may choose to leverage the combined benefits of both cannabinoids. Furthermore, this knowledge assists users in selecting appropriate dosing and product types according to their individual needs and experiences, whether in medicinal or recreational contexts. Legal Status and Regulation The legal landscape surrounding THC and CBD is complicated and varies significantly across different jurisdictions. THC’s psychoactive effects have led to stringent regulations and prohibitions in many areas. In some countries and regions, THC is classified as a controlled substance, limiting its use to medical patients or specific licensed settings. Conversely, while CBD has garnered much attention for its potential health benefits, its legal status also varies. In many jurisdictions, CBD derived from industrial hemp with low THC content (below 0.3 percent) is often legal and widely available. Consumers should be aware that the legal status of THC and CBD can change rapidly, especially in light of evolving perceptions of cannabis federally and at the state level. Where THC may be fully legal for both medical and recreational use in one state, another may still impose strict restrictions or prohibition. Likewise, CBD laws can be complex and nuanced; consumers must navigate labeling laws, quality regulations, and the distinction between hemp-derived and marijuana-derived products. As legality continues to evolve, staying informed is crucial. Individuals should consult local laws before obtaining or using THC or CBD products to avoid legal repercussions. Furthermore, as more scientific research emerges, there may be shifts in public perception, leading to improved regulations and increased accessibility for consumers. Engaged citizens and consumers can contribute to positive change by advocating for sensible, evidence-based cannabis policies that promote safe and legal access to both THC and CBD. Therapeutic Benefits and Uses The therapeutic potential of THC and CBD has garnered significant interest in recent years, with both cannabinoids being investigated for their respective medicinal properties. THC is well-researched for its ability to alleviate various symptoms, particularly chronic pain, nausea, and loss of appetite. Medical cannabis, often rich in THC, has been utilized by patients undergoing chemotherapy to mitigate nausea and stimulate appetite, showcasing its effectiveness in treating specific medical conditions. On the other hand, CBD is often favored for its potential therapeutic applications without the high associated with THC. Studies have suggested that CBD may help alleviate anxiety, inflammation, and seizures, with notable success in treating conditions such as epilepsy and multiple sclerosis. This versatility makes CBD a popular choice for patients seeking natural alternatives to conventional pharmaceuticals, particularly for those who may be sensitive to the psychological effects of THC. It is essential to note that while both cannabinoids have demonstrated therapeutic potential, individual responses may vary widely. Patients should consult healthcare providers familiar with cannabis to develop a tailored treatment plan that incorporates their specific health needs and preferences. The growing body of research indicates that the combination of THC and CBD can often yield meaningful results, highlighting the power of the entourage effect, where the presence of both cannabinoids enhances their therapeutic effects compared to isolated compounds. Potential Side Effects and Considerations As with any substance, there may be side effects associated with the consumption of THC and CBD. THC, in particular, is known to produce side effects such as dry mouth, increased heart rate, and short-term memory impairment. Moreover, some individuals may experience heightened anxiety or paranoia, especially at higher doses or in susceptible individuals. These side effects warrant careful dosing and consideration, particularly for new users or those with preexisting anxiety disorders. CBD is generally well-tolerated, and side effects are reported to be relatively mild in comparison to THC. Some users may experience fatigue, changes in appetite, or gastrointestinal issues, though these effects are not common. Nonetheless, the diverse range of individuals consuming CBD means that responses can vary widely, underscoring the importance of informed and responsible use. It is also crucial for consumers to consult with medical professionals when considering the use of THC or CBD, especially when taking other medications. CBD, while generally safe, can interact with certain medications, leading to adverse effects or reduced effectiveness. Additionally, because THC may impair cognitive and motor functions, activities such as driving or operating heavy machinery should be avoided until users understand how THC affects their individual physiology. Therefore, knowledge of the potential side effects coupled with thoughtful consideration can ensure safer consumption practices for both THC and CBD users. Summarizing the Key Differences In conclusion, understanding the key differences between THC and CBD is essential for informed cannabis consumption. THC, the psychoactive compound that induces euphoria, is primarily used for recreational purposes and certain medical applications. Its effects can be profound, bringing relief for individuals suffering from pain or nausea but also carrying a risk of side effects, including anxiety or paranoia. CBD, on the other hand, is appreciated for its therapeutic effects without the high, making it an appealing option for those looking to enhance their well-being without psychoactive effects. The ongoing evolution of cannabis laws reflects a growing acceptance of both cannabinoids, with CBD particularly enjoying broader legal status. As research continues to unveil the benefits and applications of THC and CBD, consumers are encouraged to remain informed about their local regulations and varying products. This ensures that they can choose the most appropriate forms of cannabis for their needs and conditions. Ultimately, both THC and CBD hold significant potential for therapeutic application, and understanding their unique effects can empower users to make educated choices. Whether used in tandem for their combined efficacy or separately to target specific needs, the intricate relationship between these two cannabinoids illustrates the complex nature of cannabis, inviting further exploration and understanding. The future of cannabis promises to be rich with discovery as more individuals advocate for expanded access and research, paving the way for enhanced health and well-being through responsible cannabis use. Is CBD Oil Legal? Understanding the Legal Landscape in 2024link product here https://ouchtmedo.printify.me/product/15522780 Struggling with sleepless nights? 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What do you think? #carnivalcruise #cruiseship #cruise #cbd #cbdgummies #cruisevlog #news #cruisenews #travelnews #carnivalcruiseline #carnivalhorizon #fypThese Babies Put Me Outtt Golinutrition Melatonin Sleep Gummies Goodnight Tiktok ShopMetallica's official music video for “One,” from the album “...And Justice for All.” Subscribe for more videos: https://metallica.lnk.to/subscribe Listen to Metallica: https://metallica.lnk.to/listen Directed by Bill Pope and Michael Salomon Filmed in December 1988 in Long Beach, CA Video Premiere Date: January 22, 1989 Follow Metallica: Website & Store: http://www.metallica.com Official Live Recordings: http://www.livemetallica.com Instagram: http://www.instagram.com/metallica Facebook: http://www.facebook.com/metallica Twitter: http://www.twitter.com/metallica © 1989 Blackened Recordings #Metallica #AndJusticeForAllMagnesium Sleep Gummies Best Relaxation GummiesThis video is for research only. New Hemp Oil Recipe for Cold Process Soap. will it work? can i do it? Want to see me experiment? Donate for the vet bills to get rescue kitties and mom kitty fixed to my paypal account friends and family plus please leave a note with directions on money use. Mom or Kittens or Such. All money will be used for the kitties and mom. I will do updates via video on youtube and on my facebook page... https://www.facebook.com/KimberlyMcnuttEssentialSoap/ see us Rescue her video https://youtu.be/eCpwG1obxSo thank you for using my essential depot link.. http://www.essentialdepot.com/SFNT.html?&affiliate_no=552 Help support Essential Soap as a Patreon https://www.patreon.com/user?u=5552176 find free soap recipes www.kimberlymcnutt.com buy soap from me www.essential-soap.com My Soapers Help Group Page on Facebook https://www.facebook.com/groups/EssentialSoap/ Follow me on facebook page https://www.facebook.com/KimberlyMcnuttEssentialSoap Help Deep Digger Dan with his charity Rays of Sunshine by clicking on the link..' https://www.justgiving.com/deepdiggerdan/4w350m3/Donate?clientCache=True#MessageAndAmountWana Wellness Cbd GummiesIn this week's episode, we explore the growing world of delta-8 THC—how it compares to delta-9 THC, what recent research reveals about its effects when consumed orally, and what those differences might mean for users. We also discuss a pediatric case involving the accidental ingestion of delta-8 THC gummies, highlighting the clinical presentation, management, and the testing challenges that can arise. Hope you enjoy! Links to papers we discussed: https://doi.org/10.1016/j.drugalcdep.2025.112676 https://pmc.ncbi.nlm.nih.gov/articles/PMC8594112/ https://www.sciencedirect.com/science/article/abs/pii/S0376871625001371?via%3Dihub Disclaimer: All opinions are our own. Find us on instagram: @the_tox_lab Email us here: [email protected]