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To all those who are confused about the differences between THC and CBD, this article will provide you with some basic insights on significant differences between both these cannabinoids and which one among these is entirely safe to consume. Psychoactive effects: Differences between CBD and THC One of the major differences between THC and CBD is their psychoactive component. THC is the cannabinoid that is responsible for inducing high or getting you stoned. It is the main compound found in marijuana plant and is psychoactive in nature. THC directly interacts with the CB1 receptors found in the endocannabinoid system (ECS) in the brain and the central nervous system and results in a euphoric feeling that you get after consuming it. On the other hand, CBD does not makes you high as it is non-psychoactive. CBD is derived from the hemp plant and hemp contains the least amount of THC, so it does not make one high. CBD does not interact directly with the CB1 receptors thus causing no high at all. It indirectly interacts with the ECS. So, CBD is considered as an antagonist of CB1 receptors. Medical Applications: CBD vs. THC Both CBD and THC have various medical benefits and uses. THC is mostly used for its euphoric properties as it induces a high while consumed. It is used for relaxing and pain-relieving benefits. CBD, on the other hand, is used to treat health issues such as arthritis, anxiety, epilepsy, OCD, Autism and more. Let’s find this out in detail. THC is used for: Providing relaxation and euphoria Mostly for recreational purposes Stimulate appetite Pain-Killer Relaxes Muscles Sleeping and drowsiness CBD is used for: Treating Anxiety Treating Inflammation As a painkiller Treating Epilepsy Treating Parkinson’s and OCD Legal Status: CBD vs. THC The legal status of both these cannabinoids is different. 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