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The disease is characterized by a loss of dopamine-producing neurons in the substantia nigra, which is an area of the brain responsible for movement. Cannabis, specifically CBD, has shown promise in treating some of the symptoms of PD. In this video we will define Parkinson’s disease and cannabis, explain how cannabis can help with PD, and physician perspectives on prescribing cannabis. This video was created by Demystifying Medicine students Simran Matharu, Mahek Minhas and Micaela McNulty in collaboration with the McMaster Demystifying Medicine Program Copyright McMaster University 2021 For more information visit: https://www150.statcan.gc.ca/n1/pub/82-003-x/2014011/article/14112-eng.htm Time Stamps: Introduction/What is Parkinson’s Disease? → 00:00 - 01:23 What is Cannabis? → 01:24 - 02:34 How Can Cannabis Help With Parkinson’s? → 02:35 - 05:09 Physician Perspectives → 05:10 - 07:19 Conclusion → 07:20 - 07:52 References: Bega, D., Simuni, T., Okun, M. S., Chen, X., & Schmidt, P. (2016). Medicinal cannabis for Parkinson's disease: Practices, beliefs, and attitudes among providers at national Parkinson Foundation centers of excellence. Movement Disorders Clinical Practice, 4(1), 90-95. Benner, E. J., Banerjee, R., Reynolds, A. D., Sherman, S., Pisarev, V. M., Tsiperson, V., Nemachek, C., Ciborowski, P., Przedborski, S., Mosley, R. L., & Gendelman, H. E. (2008). Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PloS one, 3(1), e1376. Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2009). The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology, 56, 235–243. de Lau, L. M., & Breteler, M. M. (2006). Epidemiology of Parkinson’s disease. The Lancet Neurology, 5(6), 525–535. Edelstein, O. E., Wacht, O., Isralowitz, R., Reznik, A., & Bachner, Y. G. (2020). Beliefs and attitudes of graduate gerontology students about medical marijuana use for Alzheimer’s and Parkinson’s disease. Complementary Therapies in Medicine, 52, 102418. Gardiner, K. M., Singleton, J. A., Sheridan, J., Kyle, G. J., & Nissen, L. M. (2019). Health professional beliefs, knowledge, and concerns surrounding medicinal cannabis – A systematic review. PLOS ONE, 14(5), e0216556. Hauser, R. A., Rascol, O., Korczyn, A. D., Jon Stoessl, A., Watts, R. L., Poewe, W., De Deyn, P. P., & Lang, A. E. (2007). Ten-year follow-up of Parkinson's disease patients randomized to initial therapy with ropinirole or levodopa. Movement disorders: official journal of the Movement Disorder Society, 22(16), 2409–2417. Jankovic, J. (2008). Parkinson’s disease: Clinical features and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry, 79(4), 368–376. Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L. E., Huang, X.-F., Liu, K., Arnold, J. C., & McGregor, I. S. (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443–457. Lang, A. E., & Lozano, A. M. (1998). Parkinson’s Disease. New England Journal of Medicine, 339(16), 1130–1143. Laun, A. S., & Song, Z. H. (2017). GPR3 and GPR6, novel molecular targets for cannabidiol. Biochemical and biophysical research communications, 490(1), 17–21. Marras, C., Beck, J. C., Bower, J. H., Roberts, E., Ritz, B., Ross, G. W., Abbott, R. D., Savica, R., Van Den Eeden, S. K., Willis, A. W., & Tanner, C. (2018). Prevalence of Parkinson’s disease across North America. Npj Parkinson’s Disease, 4(1), 21. Nutt J. G. (2000). Response to L-dopa in PD: the long and the short of it. Neurology, 54(10), 1884–1885. https://doi.org/10.1212/wnl.54.10.1884 Oeckl, P., Hengerer, B., & Ferger, B. (2014). G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology, 257, 1–9. https://doi.org/10.1016/j.expneurol.2014.04.010 Severe Spasticity. (2020). https://lioresal.com/severe-spasticity/. Venderová, K., Růzicka, E., Vorísek, V., & Visnovský, P. (2004). Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms. Movement disorders: official journal of the Movement Disorder Society, 19(9), 1102–1106. https://doi.org/10.1002/mds.20111 Wang, M., Wang, Y.-H., Avula, B., Radwan, M. M., Wanas, A. S., Mehmedic, Z., van Antwerp, J., ElSohly, M. A., & Khan, I. A. (2017). Quantitative Determination of Cannabinoids in Cannabis and Cannabis Products Using Ultra-High-Performance Supercritical Fluid Chromatography and Diode Array/Mass Spectrometric Detection. 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PURCHASE CBD OIL HERE: http://bit.ly/2BZD1fv - Coupon Code: Branden - 5% Off.Harmony Flow CBD Gummies Reviews: 90% Satisfaction RateOfficial Live Video for "Way Maker" by Leeland Subscribe to Our Youtube Channel: https://www.youtube.com/c/LeelandOfficial?sub_confirmation=1 Listen: https://slinky.to/Leeland-CityofGodAlbum Listen to Leeland's new record: https://slinky.to/Leeland-CityofGodAlbum -------------------------------------------------------------------------------- Connect with Leeland Website ► https://www.leelandonline.com Instagram ► https://www.instagram.com/leelandofficial/ Facebook ► https://www.facebook.com/leeland Twitter ► https://twitter.com/leelandofficial TikTok ► https://www.tiktok.com/@Leelandmusic --------------------------------------------------------------------------------- Lyrics Verse 1 You are here, moving in our midst I worship You, I worship You You are here, working in this place I worship You, I worship You You are here, moving in our midst I worship You, I worship You You are here, working in this place I worship You, I worship You Chorus You are Waymaker, miracle worker Promise keeper, light in the darkness My God, that is who You are You are Waymaker, miracle worker Promise keeper, light in the darkness My God, that is who You are Verse 2 You are here, touching every heart I worship You, I worship You You are here, healing every heart I worship You, I worship You Verse 3 You are here, turning lives around I worship You, I worship You You are here, mending every heart I worship You, yeah, I worship You, Lord Refrain That is who You are Oh, that is who You are (That is who You are) Oh, and that is who You are (That is who You are) My Jesus, that is who You are (That is who You are) Oh, we lift You up, that is who You are (That is who You are) My Jesus Bridge Even when I don't see it, You're working Even when I don't feel it, You're working You never stop, You never stop working You never stop, You never stop working ------------------------------------------------------------------------------- WayMaker Artists: Leeland Writers: Sinach © 2016 Sinach (adm at CapitolCMGPublishing.com, excluding the UK & Europe which is adm by Integrity Music) CCLI # 7115744 #WayMaker #Leeland #BetterWord #officialmusicvideo #sinachNidra Nutrition Sleep Well Gummies Restful SleepShop sleep gummies for better rest #fok #sleeping #fallasleep #shopblackfridayHarmony Wave Cbd Gummies Must Watch Before Buying In 2025PLIX Deep Sleep Nini Mints Review & Exposed , Side Effect ❌ in Hindi / Sleep medicine Side Effects 🚫. 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Sending good vibes!✨ LIKE 👍 COMMENT ✅ SUBSCRIBE 💚 http://bit.ly/ThatHighCouple ---------------------------------------------------------- ⭐PATREON CLUB ➡ http://bit.ly/ThatHighCouplePatreon 🔹Instagram: (http://instagram.com/thathighcouple) 🔹Facebook: (http://bit.ly/ThatHighCoupleFB) 🔹Twitter: (http://twitter.com/thathighcouple_) 🔴 SUBSCRIBE if you want more peace, love, and positivity in the cannabis community! --------------------------------------------------------- 📢 We LIVE broadcast on the last Tuesday of every month at 7:00pm PST (GMT -8:00). Tune in, smoke up, and participate in a live Q&A. ---------------------------------------------------------- 📫 WRITE THAT HIGH COUPLE Alice & Clark P.O. 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Dr. Nan Wise talks about her 40 + years of clinical experience with clients successfully self-treating orgasm and desire challenges with cannabis.Mango Tajin Cannabis Gummies With Chamoy Flight BitesBring Me The Horizon – teardrops (official video) POST HUMAN : SURVIVAL HORROR - the new album out now: http://bmthorizon.co/PH.SH listen to ‘teardrops’ here: http://bmthorizon.co/teardrops tickets for our 2021 tour dates: http://www.bmthofficial.com/live/ spotify: http://bmthorizon.co/teardrops/spotify apple music: http://bmthorizon.co/teardrops/applemusic itunes: http://bmthorizon.co/teardrops/itunes youtube Music: http://bmthorizon.co/teardrops/youtubemusic amazon Music: http://bmthorizon.co/teardrops/amazonmusic deezer: http://bmthorizon.co/teardrops/deezer follow bring me the horizon: instagram: https://instagram.com/bringmethehorizon twitter: https://twitter.com/bmthofficial facebook: https://facebook.com/bmthofficial youTube: https://youtube.com/user/BMTHchannel newsletter: http://bmthorizon.co/newsletter merch store:http://bmthorizon.co/horizonsupply credits: written, directed & edited by oliver sykes producer: craig dixon dop: gaul porat costume & mua: natasha lawes production designer: mimi windsor demon: rebecca rennison underwater cameraman: zac macauley underwater gaffer: neil blackman colourist: vlad barin Lyrics: teardrops we hurt ourselves for fun force feed our fear until our hearts go numb addicted to a lonely kind of love. what i wanna know.. is how we got this stressed out, paranoid everything is going dark nothing makes me sadder than my head. i’m running out of teardrops let it hurt ‘til it stops i can’t keep my grip i’m slipping away from me oh god, everything is so fucked but i can’t feel a thing the emptiness is heavier than you think. i’m tripping on the edge high as a kite, i’m never coming down. and if you hear me guess you know how it feels to be alone so how’d we get this stressed out? paranoid everything is going dark nothing makes me sadder than my head. suicidal, violent tragic state of mind. lost my halo, now i’m my own anti-christ. #BringMeTheHorizon #Teardrops #BringMeTheHorizonTeardrops #BMTHTeardropsAna Marie Schick Using Magnesium For Sleep Fitness Why You Should Skip The GummiesNeuro Surgeon Dr. Ranganatham explains about Melatonin hormone and its role in human body helping us to sleep. 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