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Parkinson’s disease, also known as PD, is the second most common neurodegenerative disorder. The disease is characterized by a loss of dopamine-producing neurons in the substantia nigra, which is an area of the brain responsible for movement. Cannabis, specifically CBD, has shown promise in treating some of the symptoms of PD. In this video we will define Parkinson’s disease and cannabis, explain how cannabis can help with PD, and physician perspectives on prescribing cannabis. This video was created by Demystifying Medicine students Simran Matharu, Mahek Minhas and Micaela McNulty in collaboration with the McMaster Demystifying Medicine Program Copyright McMaster University 2021 For more information visit: https://www150.statcan.gc.ca/n1/pub/82-003-x/2014011/article/14112-eng.htm Time Stamps: Introduction/What is Parkinson’s Disease? → 00:00 - 01:23 What is Cannabis? → 01:24 - 02:34 How Can Cannabis Help With Parkinson’s? → 02:35 - 05:09 Physician Perspectives → 05:10 - 07:19 Conclusion → 07:20 - 07:52 References: Bega, D., Simuni, T., Okun, M. S., Chen, X., & Schmidt, P. (2016). Medicinal cannabis for Parkinson's disease: Practices, beliefs, and attitudes among providers at national Parkinson Foundation centers of excellence. Movement Disorders Clinical Practice, 4(1), 90-95. Benner, E. J., Banerjee, R., Reynolds, A. D., Sherman, S., Pisarev, V. M., Tsiperson, V., Nemachek, C., Ciborowski, P., Przedborski, S., Mosley, R. L., & Gendelman, H. E. (2008). Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PloS one, 3(1), e1376. Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2009). The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology, 56, 235–243. de Lau, L. M., & Breteler, M. M. (2006). Epidemiology of Parkinson’s disease. The Lancet Neurology, 5(6), 525–535. Edelstein, O. E., Wacht, O., Isralowitz, R., Reznik, A., & Bachner, Y. G. (2020). Beliefs and attitudes of graduate gerontology students about medical marijuana use for Alzheimer’s and Parkinson’s disease. Complementary Therapies in Medicine, 52, 102418. Gardiner, K. M., Singleton, J. A., Sheridan, J., Kyle, G. J., & Nissen, L. M. (2019). Health professional beliefs, knowledge, and concerns surrounding medicinal cannabis – A systematic review. PLOS ONE, 14(5), e0216556. Hauser, R. A., Rascol, O., Korczyn, A. D., Jon Stoessl, A., Watts, R. L., Poewe, W., De Deyn, P. P., & Lang, A. E. (2007). Ten-year follow-up of Parkinson's disease patients randomized to initial therapy with ropinirole or levodopa. Movement disorders: official journal of the Movement Disorder Society, 22(16), 2409–2417. Jankovic, J. (2008). Parkinson’s disease: Clinical features and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry, 79(4), 368–376. Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L. E., Huang, X.-F., Liu, K., Arnold, J. C., & McGregor, I. S. (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443–457. Lang, A. E., & Lozano, A. M. (1998). Parkinson’s Disease. New England Journal of Medicine, 339(16), 1130–1143. Laun, A. S., & Song, Z. H. (2017). GPR3 and GPR6, novel molecular targets for cannabidiol. Biochemical and biophysical research communications, 490(1), 17–21. Marras, C., Beck, J. C., Bower, J. H., Roberts, E., Ritz, B., Ross, G. W., Abbott, R. D., Savica, R., Van Den Eeden, S. K., Willis, A. W., & Tanner, C. (2018). Prevalence of Parkinson’s disease across North America. Npj Parkinson’s Disease, 4(1), 21. Nutt J. G. (2000). Response to L-dopa in PD: the long and the short of it. Neurology, 54(10), 1884–1885. https://doi.org/10.1212/wnl.54.10.1884 Oeckl, P., Hengerer, B., & Ferger, B. (2014). G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology, 257, 1–9. https://doi.org/10.1016/j.expneurol.2014.04.010 Severe Spasticity. (2020). https://lioresal.com/severe-spasticity/. Venderová, K., Růzicka, E., Vorísek, V., & Visnovský, P. (2004). Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms. Movement disorders: official journal of the Movement Disorder Society, 19(9), 1102–1106. https://doi.org/10.1002/mds.20111 Wang, M., Wang, Y.-H., Avula, B., Radwan, M. M., Wanas, A. S., Mehmedic, Z., van Antwerp, J., ElSohly, M. A., & Khan, I. A. (2017). Quantitative Determination of Cannabinoids in Cannabis and Cannabis Products Using Ultra-High-Performance Supercritical Fluid Chromatography and Diode Array/Mass Spectrometric Detection. Journal of Forensic Sciences, 62(3), 602–611. https://doi.org/10.1111/1556-4029.13341

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Cannabidiol, commonly known as CBD, is a compound found in cannabis plants that has gained popularity in recent years for its potential therapeutic benefits. With the growing interest in CBD products, understanding its half-life is important for consumers to make informed decisions about dosing and frequency of use. In this article, we will explore what the half-life of CBD is and why it matters.

The Basics of Half-Life

Half-life refers to the amount of time it takes for half of a substance to be metabolized or eliminated from the body. In the case of CBD, the half-life can vary depending on a variety of factors, including the method of administration, dosage, and individual metabolism. However, on average, CBD has a half-life of approximately 18 to 32 hours.

One important thing to note is that the half-life of CBD does not mean that it will be completely out of your system after this time. It simply means that half of the dose you took will have been processed by your body. It can take several days for CBD to be fully eliminated from your system.

Understanding the half-life of CBD can help you determine how often you need to take it to maintain a consistent level in your system. For some people, taking CBD once a day may be sufficient, while others may need to take it multiple times a day to achieve the desired effects.

Factors Affecting Half-Life

Several factors can influence the half-life of CBD, including the method of administration. When CBD is ingested orally, such as in the form of oils or edibles, it has to pass through the digestive system before being absorbed into the bloodstream. This can result in a longer half-life compared to other methods, such as vaping or sublingual administration, where the CBD is absorbed more quickly.

Another factor that can affect the half-life of CBD is the dosage. Higher doses of CBD may take longer to be metabolized and eliminated from the body, resulting in a longer half-life. Additionally, individual factors such as metabolism, body weight, and overall health can also play a role in how quickly CBD is processed by the body.

It’s important to note that while the half-life of CBD can provide some general guidance, it is not a one-size-fits-all measure. Each person may respond differently to CBD based on their unique physiology and personal factors. Experimenting with dosing and frequency of use can help you find what works best for you.Cbn Sleep Gummies Sleepgummies Cbnsleepgummies

Implications for CBD Users

For CBD users, understanding the half-life of the compound can help them make informed decisions about how and when to take it. If you are using CBD for a specific purpose, such as managing pain or anxiety, knowing the half-life can help you determine the optimal dosing schedule to maintain consistent levels in your system.

Some people may find that taking CBD multiple times a day provides more consistent relief, while others may only need to take it once daily. By experimenting with different dosing schedules and paying attention to how you feel, you can find the right balance that works for you.

Ultimately, the half-life of CBD is just one piece of the puzzle when it comes to using this compound effectively. It’s important to listen to your body and work with a healthcare provider to develop a personalized CBD regimen that meets your individual needs.

Conclusion

In conclusion, understanding the half-life of CBD is essential for anyone using this compound for therapeutic purposes. By knowing how long CBD stays in your system and how it is metabolized, you can optimize your dosing schedule to achieve the desired effects. Keep in mind that the half-life of CBD can vary depending on several factors, so it may take some trial and error to find what works best for you. As always, consult with a healthcare provider before starting any new supplement regimen to ensure it is safe and effective for your specific needs.

Remember to start low and go slow when experimenting with CBD dosing, and pay attention to how your body responds. With patience and careful monitoring, you can find the right balance of CBD that works best for you.

Thank you for reading and we hope this article has helped you gain a better understanding of the half-life of cannabidiol. If you have any further questions or concerns, feel free to reach out to a healthcare provider or CBD specialist for personalized guidance.

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One alternative that has been gaining popularity among pet owners is CBD oil. CBD, or cannabidiol, is a compound found in the cannabis plant that has been shown to have a wide range of therapeutic benefits. Honest Paws CBD oil is specifically formulated for pets and is made with 100% pure CBD extract, ensuring that your furry companion gets all the benefits without any psychoactive effects.

Honest Paws CBD oil is available in various strengths and flavors to suit your pet’s individual needs and preferences. Whether you have a small breed dog suffering from separation anxiety or an older cat dealing with chronic pain, Honest Paws has a product that can help.

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One of the main reasons pet owners turn to CBD oil is its potential to manage a variety of common health issues in pets. CBD has been shown to have anti-inflammatory, analgesic, and anti-anxiety properties, making it a versatile option for pets suffering from conditions like arthritis, cancer, and separation anxiety.

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Additionally, CBD oil is a natural and safe alternative to traditional medications, which can often come with unwanted side effects. Honest Paws CBD oil is free of additives, preservatives, and harmful chemicals, making it a gentle and effective option for pets of all ages and breeds.

How to Choose the Right Honest Paws CBD Oil for Your Pet

When shopping for CBD oil for your pet, it’s important to consider factors such as the potency of the product, your pet’s size and weight, and any specific health concerns they may have. Honest Paws offers a range of CBD oil products, including tinctures, treats, and balms, each formulated for different purposes and dosages.

If you have a small breed dog or a cat, you may want to start with a lower potency CBD oil and gradually increase the dosage as needed. Larger breed dogs or pets with severe health issues may benefit from a higher potency product to achieve the desired effects.

It’s also important to consult with your veterinarian before introducing CBD oil to your pet’s routine, especially if they are currently taking any medications or have underlying health conditions. Your vet can help you determine the right dosage and monitor your pet’s response to the treatment to ensure their safety and well-being.

Potential Side Effects of Honest Paws CBD Oil for Pets

While CBD oil is generally considered safe for pets, there are some potential side effects to be aware of. Some pets may experience mild drowsiness, dry mouth, or gastrointestinal upset when first starting CBD oil treatment. These side effects are typically mild and temporary, but if they persist or worsen, it’s important to discontinue use and consult with your veterinarian.

It’s also essential to choose a high-quality CBD oil product like Honest Paws to ensure that your pet gets the full benefits without any harmful additives or contaminants. Look for products that are lab-tested for purity and potency and free of any potential allergens or toxins that could harm your pet.

Overall, Honest Paws CBD oil for pets offers a natural and effective way to improve your furry friend’s quality of life. With the right product, dosage, and guidance from your veterinarian, you can help your pet manage their health issues and enjoy a happier and healthier life.

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Summary and FAQ

Overall, Honest Paws CBD oil for pets is a safe and effective option for managing a variety of common health issues in pets. With its anti-inflammatory, analgesic, and anti-anxiety properties, CBD oil can help improve your pet’s overall well-being and quality of life. When choosing a CBD oil product for your pet, it’s essential to consider factors such as potency, dosage, and any specific health concerns they may have. Always consult with your veterinarian before starting any new treatment to ensure your pet’s safety and well-being.

Are there any side effects of Honest Paws CBD oil for pets?

While CBD oil is generally considered safe for pets, some may experience mild side effects such as drowsiness, dry mouth, or gastrointestinal upset. These side effects are typically mild and temporary but should be monitored closely. If side effects persist or worsen, discontinue use and consult with your veterinarian.

Can I give Honest Paws CBD oil to all pets?

CBD oil is safe for most pets, including dogs, cats, and even horses. However, it’s essential to choose the right product and dosage for your pet’s specific needs and consult with your veterinarian before starting any new treatment. Always follow the recommended guidelines and monitor your pet’s response to the treatment to ensure their safety and well-being.

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