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El CBD es el cannabinoide predominante en el cáñamo y este contiene niveles muy bajos de THC; tan bajos, que no producen efectos psicoactivos, incluso en el mercado se encuentran algunos nutraceúticos que no contienen THC. RECOMENDACIONES: 1- Antes de automedicarte con cannabis consulta con un médico de confianza o tu médico personal. Si éste carece de conocimientos sobre el uso medicinal de los cannabinoides busca recomendación de uno que tenga el conocimiento. 2- Antes de consumir CBD sin recomendación profesional, es imprescindible consultar con tu médico si estás embarazada o tengas intención de estarlo y/o en el caso de que padezcas algún trastorno psiquiátrico, así como si estás utilizando cannabis y experimentas algún tipo de efecto secundario anormal. La adolescencia es también un periodo de gran vulnerabilidad a los efectos neurológicos no deseados causados por el cannabis. 3- Las instituciones médicas de muchos países están para preparadas para asesorarte en tu correcto tratamiento con cannabinoides, con información relativa a las vías de administración, dosis, composiciones, etc. 4- El producto de cannabis medicinal que vayas a utilizar debe poseer análisis y/o certificaciones fiables sobre su calidad y composición, igualmente sobre la ausencia de productos tóxicos, adicionalmente debe tener en regla los permisos de utilización y comercialización emitidos por las entidades reguladoras de medicamentos y alimentos de tu país. 5- El CBD es un nutraceútico muy seguro (no es citotóxico, ni mutagénico, ni es letal por sobredosis…), pero obviamente no es inocuo y puede tener efectos secundarios, infórmate bien acerca de ellos antes de su uso, y consulta además si pueden existir contraindicaciones o interacciones con tu medicación habitual. 6- Si consumes CBD sin THC no es posible que des positivo en los análisis de tráfico, pero, si consumes THC si es posible que des positivo dependiendo de las dosis. 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While there are multiple compounds in cannabis that offer medicinal effects, and many more that modulate the impact of THC, there are none with such a psychoactive impact as THC. THC Effect The effect of consuming decarboxylated THCA, or THC, in high doses can cause near hallucinations for some. Although the effect is not technically “intoxicating,” it is certainly inebriating and often very psychedelic. The Molecule That Started the War It is this cannabinoid that is the target of the now fading drug war, which characterized cannabis as a dangerous and addictive drug. In the absence of THCA, there may never have been a war against cannabis. Original Source is CBGA THCA, like CBDA, is synthesized from CBGA in the apoplastic space of the secretory vesicle in the trichome. The enzyme that does the work is THCAS or THCA synthase. Again, there is a peroxide byproduct which is toxic to the cell, and therefore THCAS biosynthesis must occur in the trichome secretory vessel. THC and Regulations Current regulations require that all CBD hemp flowers with a THC content greater than 0.3% are thereby classified as “marijuana,” and must be destroyed. There are a few exceptions to the rule of THCAS producing THCA, and CBDAS producing CBDA. Biological Expectations vs Regulations Research from Oregon CBD company has shown that in vitro, CBDAS will produce one part THCA for every 20 parts CBDA. Therefore, with cannabinoid contents of hemp exceeding 20%, it may be totally unreasonable to have the THCA content requirement set to 0.3% or less, because we can biologically expect a minimum of 1% THCA for every 20% of CBDA produced by CBDAS, the required synthase for CBDA production. THC Interactions THC primarily interacts with the CB1 receptor in the endocannabinoid system. For the majority, these receptors are found on the nervous system tissues. 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Pharmaceutical Press, London, 2004: pages. 205-228.] First; we must understand that the absorption of CBD from the gastrointestinal tract is erratic, resulting in a variable pharmacokinetic profile … Then the study showed that bioavailability from oral delivery (capsules) was estimated to be 6% due to significant first-pass metabolism – [note that CBD gummies and beverages are similar] So here is the net result of swallowing a 25mg CBD soft-gel capsule: First; It was found that,, delivery of less than a staggering 2.5mg CBD was available for the body to use… Therefore the relative cost to consumer is 10 times for bioavailable CBD… That means a bottle of CBD capsules selling for $60 has an effective price of $600… Ouch This next study has to do with Chewing gum with infused Caffeine We will take a look at “The Rate of Absorption and Relative Bioavailability of Caffeine Administered in Chewing Gum Versus Capsules to Normal Healthy Volunteers.” This information comes from a publication by [Kamimori, et al, International Journal of Pharmaceutics, 234 (1), p.159-167, March 2002] They found that caffeine (100mg) in a chewing gum was absorbed at a significantly faster rate (five times) with bioavailability comparable to ingested caffeine capsules of over 80%... Chewing gum is a convenient and effective means of rapidly administering caffeine as shown for military and exercise activities ,,, This same study could apply to CBD in chewing gum So what does all this have to do with CBD and the delivery of its medicinal benefits? . Well how you consume the product can affect how potent it is,, and how easy it is to take. Did you know that Over 40% of American Adults Report Experiencing Difficulty Swallowing Pills,, once again this information comes from a [Harris Interactive National Survey and Schwarz Pharma, 2004] The fact is,,, many people failed to take medication because of swallowing difficulties,,, And most people have no problems swallowing food or liquid which results in these,,, medical implications which are that 14% delayed taking doses of their medication, 8% skip doses and 4% discontinued using their medication …that seems to be quite alarming. We found that people are seeking alternative forms of the consumption of medication versus pills and capsules: Why? One, For the ability to easily transport medications, – gum and mints travel well ,,, Two,, The ease of administration, – gum and mints are easy to use,,, Three, they require literally no preparation because, gum and mints are ready from the pack,,, And, there is no need for water such as when you have to swallow pills, – no water for gum and mints,,, Finally better taste, – gums and mints have a great taste! 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