Transcript Mastering Dosage: How to Optimize Your CBD Gummy IntakeScientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms and demonstrating benefits to mouse neurons. Two of the most well-known components of marijuana are tetrahydrocannabinol, or THC, and cannabidiol, or CBD. They have the same atomic composition, but differ in structure. THC provides the high that is often associated with marijuana use. CBD, on the other hand, is considered benign and seems to possess antipsychotic, pro-cognitive, anti-inflammatory, anti-seizure, and antioxidant properties. In June 2018, the FDA approved Epidiolex, the first CBD-based prescription medication, for rare forms of epilepsy, and later for the treatment of some seizures. However, the research into both compounds is still in its infancy. In this new study, scientists dived deeper into the workings of CBD using C. elegans nematode worms, which is considered a good model for initial studies, including in geroscience. Previous research has shown that CBD can increase lifespan in C. elegans and zebrafish, but the mechanism had remained unknown. Another study found that CBD induces autophagy in cultured neuronal cells. In this new study, the researchers attempted to investigate the relationship between these two effects. Autophagy is the process of clearing away various cellular debris, such as misfolded proteins and dysfunctional organelles. Unsurprisingly, this maintenance system appears to be very important for health and longevity in numerous model organisms and in humans. The CBD treatment greatly increased autophagic activity in several tissues and cell types, most drastically by 78% in neurons. The researchers then validated those findings in vitro on several types of cells, including mouse primary hippocampal neurons. Importantly, impaired autophagy in the brain is considered a major cause of Alzheimer’s disease. Worms on CBD lived significantly longer than controls. The researchers also measured the worms’ healthspan. Many interventions that prolong lifespan in C. elegans often lead to functional impairment, such as decreased motility. Three popular health metrics in C. elegans that decline with age are pharyngeal pumping rate, reproductive capacity, and locomotion, and all three were significantly restored, rather than impaired, by CBD treatment. The gene SIRT1 has been a popular object of study in geroscience. One of its roles is a mediator of autophagy. By knocking out SIRT1 in mouse neurons, researchers were able to obliterate many of the benefits of CBD, pointing at a crucial role of SIRT1 in mediating CBD-induced effects. This study expands our understanding of CBD's effects, linking them to autophagy, an important process that keeps popping up on geroscientists' radars. It is encouraging that CBD demonstrates the strongest pro-autophagy effect in neurons, making it a potential anti-Alzheimer’s drug. Obviously, the fact that CBD increases autophagy in worms does not mean that using marijuana makes humans healthier, and we’ll need to see human trials on CBD and other compounds. SOURCES AND FURTHER READING ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity - https://pubmed.ncbi.nlm.nih.gov/35445360/ Effect of Cannabidiol on the Long-Term Toxicity and Lifespan in the Preclinical Model Caenorhabditis elegans - https://pubmed.ncbi.nlm.nih.gov/33998871/ Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205952/ Cannabidiol induces autophagy via ERK1/2 activation in neural cells - https://www.nature.com/articles/s41598-021-84879-2 EPIDIOLEX - https://youtu.be/zepKBzlKzdY FOOTAGE, IMAGES, AND MUSIC CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Stock footage & Images : Videoblocks.com, Shutterstock.com Music: "Elastic Vibe" by Ziv Moran PRODUCTION CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Host, Producer, & Editor - Ryan O’Shea Writer - Arkadi Mazin Art - Mattijs Vonk, Tim Maupin Executive Producer - Keith Comito #CBD #Science #LongevityMother Natures Cbd Gummies Where To Buyread Price Reviews ScamIn this conversation, Emma Davis shares her journey of creating a CBD product for animals, driven by personal experiences with pain management and a desire to help pets. She discusses the challenges of dosing and manufacturing, the complexities of marketing in a restricted industry, and her future goals for brand expansion. Emma also explains the science behind CBD and its effects on animal health, emphasizing the importance of the endocannabinoid system in managing pain and anxiety in pets. Takeaways • Emma's journey began after a serious injury and personal experience with CBD. • Her dog’s cancer remission inspired her to create CBD products for pets. • Dosing for animals is complex and varies by individual. • Marketing CBD products is challenging due to legal restrictions. • SEO and content marketing are key strategies for her business. • Hemp products are legal to sell and ship across the U.S. • Emma aims to be a leading brand in CBD for animals. • She is exploring niche markets, including products for pigs. • The potency of her products sets them apart from competitors. • Understanding the endocannabinoid system is crucial for CBD efficacy. Today's guest, Emma Davis, can be found online at: Website: https://mikkoschoice.com/ Facebook: https://www.facebook.com/Mikkoschoice LinkedIn: https://www.linkedin.com/in/emma-brayfield-02a8b1b6 Your host, Scott Turman, can be found online at: BrightRay Publishing: https://brightray.com/ Entrepreneur Website: https://scottturman.com/ LinkedIn: https://www.linkedin.com/in/scottturman/ Keywords CBD, animals, pet health, dosing, manufacturing, marketing, hemp, cannabis, endocannabinoid system, animal wellnessThc Disposable Vapes Magic Mushroom Gummies Chocolate Combine Texas(27 Jan 2023) RESTRICTION SUMMARY: ASSOCIATED PRESS Hong Kong - 27 January 2023 1. Pan of news conference by Hong Kong Customs 2. Pan of products containing cannabidiol, or CBD 3. Close of CBD products 3. Photographer taking photos of CBD products 4. Wide of news conference 5. SOUNDBITE (English) Chan Kai-ho, Divisional Commander, Customs Airport Command: “I mean, for the long run, we have to conduct education, to let the people know that CBD is kind of like dangerous drug, like heroin or cocaine. So, I mean, on the one hand we have to conduct enforcement actions, and on the other hand we have to conduct education, publicity, to let all the people know that some products in other parts of the world is not under control, but in Hong Kong, yes, CBD is under control.” ASSOCIATED PRESS ARCHIVE: Hong Kong – 13 September 2020 6. Pan of customers in Hong Kong’s first CBD cafe 7. Sign outside cafe reading (English): “free CBD coffee with any CBD product purchase” 8. Various of CBD products on sale inside cafe 9. Wide of pan of exterior of cafe 10. Customers sitting outside Hong Kong’s first CBD cafe STORYLINE: Hong Kong will ban CBD starting Wednesday, categorizing it as a “dangerous drug" and mandating harsh penalties for its smuggling, production and possession. Customs authorities made the announcement Friday. “CBD is kind of like a dangerous drug, like heroin, or cocaine,” airport customs official Chan Kai-ho told the media at press conference held on Friday organised to highlight the new regulation. Supporters say CBD can treat a range of ailments including anxiety and that, unlike its more famous cousin THC — which is already illegal in Hong Kong — CBD doesn’t get users high. Cannabidiol, derived from the cannabis plant, was previously legal in Hong Kong, where bars and shops sold products containing it. Hong Kong authorities decided last year to prohibit the marijuana-derived substance — a change that will soon go into effect. Residents were given three months from October 27 to dispose of their CBD products in special boxes set up around the city. Anyone travelling into Hong Kong with any CBD product can be prosecuted. Customs officials say they are trying to place advisories on planes to make travellers to Hong Kong aware of the new rule. Penalties include up to life in prison and Hong Kong $5 million ($638,000) in fines for importing, exporting or producing CBD. Possession of the substance can result in a sentence of up to seven years and Hong Kong $1 million ($128,000) in fines. In announcing the ban last year, the Hong Kong government cited the difficulty of isolating pure CBD from cannabis, the possibility of contamination with THC during the production process and the relative ease by which CBD can be converted to THC. Hong Kong's first CBD cafe opened in 2020 and the ban will force scores of businesses to remove CBD-infused gummies, drinks and other products, or shut down altogether. The ban is in keeping with a zero-tolerance policy toward drugs in Hong Kong, a semi-autonomous southern Chinese business hub, as well as on mainland China, where CBD was banned in 2022. =========================================================== Clients are reminded to adhere to all listed restrictions and to check the terms of their licence agreements. For further assistance, please contact the AP Archive on: Tel +44(0)2074827482 Email: [email protected]. Find out more about AP Archive: http://www.aparchive.com/HowWeWork Twitter: https://twitter.com/AP_Archive Facebook: https://www.facebook.com/APArchives Instagram: https://www.instagram.com/APNews/ You can license this story through AP Archive: http://www.aparchive.com/metadata/youtube/e3121318901b4a87987a869ab976533cBoost Your Sleep With Beast Bites Gummies Supplements3 Best Mental Health Benefits of CBD | Exploring the Potential of CBD Oil for Mental Wellness https://www.kentuckycannabiscompany.com This revised article dives into the potential mental health benefits of CBD oil, highlighting Kentucky Cannabis Company's (KCC) commitment to quality and responsible use. It emphasizes the importance of consulting with a healthcare professional before incorporating CBD into your regimen. Introduction Nestled in Kentucky's verdant Bluegrass region, Kentucky Cannabis Company (KCC) stands out as a leader in the CBD oil industry. Drawing on their agricultural heritage, KCC cultivates premium Kentucky hemp, the foundation for their high-quality CBD products. These products hold promise for enhancing mental well-being by potentially mitigating anxiety, managing stress, and aiding in alleviating depression. The Potential Benefits of KCC's CBD Oil for Mental Health Anxiety Reduction: CBD oil's potential to interact with the body's endocannabinoid system may provide a calming influence on a restless mind, offering relief from anxiety symptoms. Stress Management: KCC's CBD oil may help regulate the body's stress response, promoting emotional balance and potentially reducing physical manifestations of stress like rapid heartbeat and sweating. Additionally, CBD oil may contribute to better sleep, a crucial factor in managing stress. Mood Regulation and Potential Aid for Depression: By interacting with the endocannabinoid system, CBD oil may help regulate mood-regulating chemicals in the brain. This potential mood-balancing effect could be beneficial for those struggling with depression. KCC: A Dedication to Quality and Transparency KCC prioritizes quality throughout the production process, from meticulously selecting seeds to ensuring the final product meets the highest standards. Their commitment extends to their extraction method: butane hash oil (BHO) extraction. BHO Extraction: Capturing a Wider Range of Beneficial Compounds BHO extraction, when done correctly, is considered the gold standard. It utilizes pressurized butane to separate desired cannabinoids from the plant material, capturing a broader spectrum of beneficial compounds beyond just CBD. This full-spectrum approach is believed to yield a potentially more comprehensive and effective product for overall well-being. Beyond the Hype: KCC's Commitment to Responsible Use KCC isn't simply capitalizing on the CBD trend. Their foundation lies in a deep understanding of hemp cultivation and a dedication to providing the finest quality CBD oil. However, it's important to remember that CBD research is ongoing. Consulting with a healthcare professional before using CBD products is vital to determine if it's right for you and to establish the appropriate dosage. Finding the Right Dosage for Optimal Results The effectiveness of KCC's CBD oil can be maximized by finding a suitable dosage. This journey of discovery is individual, and it's recommended to start with a low dose and gradually increase until you find what works best for you. Exploring Specific Areas of Mental Health Anxiety and CBD Oil: While initial research suggests potential benefits, more data is needed to confirm CBD oil's impact on anxiety management. Stress Management with CBD Oil: CBD oil may be a natural tool for managing stress and promoting relaxation. However, consulting with a healthcare professional is crucial to determine the best approach for you. Depression and CBD Oil: The potential mood-regulating effects of CBD oil might offer some relief for those struggling with depression. It's important to note that CBD oil is not a replacement for professional medical advice or treatment. The Importance of Consulting a Healthcare Professional The effectiveness of CBD oil for various mental health conditions is still under investigation. Consulting with a healthcare professional is essential before incorporating CBD products into your regimen, especially if you have pre-existing medical conditions or are taking other medications. They can help you determine if CBD oil is right for you and address any potential interactions with current medications. KCC: Advancing Research on CBD Oil and Mental Wellness KCC actively participates in exploring the potential of CBD oil for mental health benefits. Here are some key areas of ongoing research: Optimal Dosage Determination: Identifying the most effective dosage for various mental health conditions is crucial. Long-Term Impacts of CBD Use: Understanding the long-term effects of CBD use on mental health is essential. Exploring Synergistic Effects: Research on how CBD interacts with other cannabinoids to potentially amplify therapeutic effects on mental well-being is ongoing. Investigating a Wider Range of Conditions: Studies are underway to explore the effectiveness of CBD oil for a broader range of mental health conditions.Crafting the Perfect Marijuana Gummies Recipe: A Step-by-Step Guidehttps://stormrock.fr/ code promo sur le vap pen ➡️ MACMAT10 code promo sur les fleurs, les extractions et les resines ➡️ MACMAT30 PEACE ✌ 🍀R&R CBD Gummies: 7 Things You Should Know Before BuyingThe Dr. Mehmet Oz show observes World Health Day With a Moving Public Service Announcement and Call To Action on Medical Marijuana. 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To be clear, the cast of the reality TV show "Shark Tank" never endorsed Mach5 Keto ACV Gummies or any other similar keto or CBD gummies products, nor did Ree Drummond, Kelly Clarkson, Kelly Osbourne, Melissa McCarthy, or any other big-name celebrities. Scammers appeared to be using the image and likeness of more celebrities for either these gummies or others without permission, as well as the gummies company without authorization. And by the way, this video only has to do with Mach5 Keto ACV Gummies. Any products with similar names have nothing to do with this. In this video, I show why people were searching for the four words Mach5 Keto ACV Gummies scam and even attempt to show some so-called reviews that really appeared to be nothing more than sponsored content. Also, I looked on a website associated with the product, whether an affiliate marketer or something else, for a customer service or support phone number and an email address. Additionally, please keep this in mind with this lengthy description: I am writing this description to compete with the “Shark Tank” scam and the other celebrities whose image and likeness are being used, so the point of my video is to educate people, but the point of this description, which might not read well, is to help people find my video. Various websites based in India such as Outlook India, Deccan Herald, Tribune India, and others, all likely feature a Mach5 Keto ACV Gummies scam about “Shark Tank,” Oprah Winfrey, Ree Drummond, and Kelly Clarkson, and some fake reviews in sponsored content articles. I show some of this in the video. These stories are sponsored content article so-called reviews and lead to product pages that may have nothing to do with the Mach5 Keto ACV Gummies scam. During the course of my research, I also looked at Facebook to see if I could find people who provided reviews or who said they fell for the scam and purchased Mach5 Keto ACV Gummies through unknown websites. Here’s what I often see: Scam websites that feature fake celebrity endorsements, such as with Tiger Woods, Dr. Phil, Dr. Oz, Dr. Sanjay Gupta, Sam Elliott, Michael Jordan, Garth Brooks, and Phil Mickelson, whose images and likenesses were being used without permission, sometimes send people to be charged $39.98, but they ultimately receive a big charge for $198 or something similar. I have seen this story about keto and CBD gummies consistently in the past, with people being charged way more than they thought they would. This usually is followed up by a refund offer for half of the amount, which still seemed wrong. The Mach5 Keto ACV Gummies scam where scammers are using celebrities’ image and likeness without authorization and the company name without permission has lots of moving parts, including a “fulfillment center” PO Box in Smyrna, Tennessee, Tampa, Florida, and Las Vegas, Nevada, that has been mentioned by commenters under my videos. I do not have all of the answers, nor did I try the product. However, follow all of the red flags that I mention and hopefully you, in consultation with your doctor, will make the right decision for you when it comes to the question of following through with these fake celebrity endorsement scams. Mach5 Keto ACV Gummies is just the latest keto or CBD gummies product that Google users are searching for with the words scam and reviews. It seems like there's a new CBD or keto gummies product name every single day, and every time Outlook India, Deccan Herald, Tribune India, and others are all publishing sponsored content articles, and other scammers are making tons of brand new Facebook pages, and there's basically a lot of weird stuff happening with all of this. In regard to all scams, my advice is this: If it seems too good to be true, it probably is. If you think that one of your favorite celebrities endorsed CBD or keto gummies, it's likely not true. I believe Martha Stewart might have a real line of CBD products, but many of the other celebrities featured in these scams have nothing to do with them. Thanks for watching, please like this video, and also subscribe. 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(P) (C) 2011 Capitol Records Nashville. All rights reserved. Unauthorized reproduction is a violation of applicable laws. Manufactured by Capitol Records Nashville, 3322 West End Avenue, 11th Floor, Nashville, TN 37203How To Make Cbd Gummies 3 Ingredient Cbd ChewsALBUQUERQUE, N.M.- The hemp-derived CBD industry is currently operating with no oversight from the government, leaving some New Mexico companies to self-regulate. “What this all boils down to is consumer protection,” said Matt Kennicott, a co-founder of Glo CBD which produces chewable CBD tablets. “This is a substance that people are putting into their bodies so we need to make sure it’s clean, it’s safe and what we say is in there is actually in there,” said Kennicott. Some people use hemp-derived CBD for pain or anxiety. However, the FDA is not currently approving any CBD products for commercial sale. Kennicott says his company follows FDA regulations and guidelines for manufacturing that apply mainly to pharmaceutical products. “As you know CBD doesn't really have any regulation around it right now but we wanted to a different company by setting the standard and following FDA regulations,” said Kennicott. 4 Investigates exposed how the CBD industry is currently operating in the dark with no government-imposed health or safety regulations. State Rep. Derrick Lente says a new law will eventually allow the state to hold all CBD companies operating in New Mexico to a common standard. “These types of rules and policies are all being made but they’ll ensure the consumer is buying a quality product from the State of New Mexico,” said Rep. Lente. In the meantime, Kennicott says his company is focused on fostering complete transparency with their product. 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Get yours here: https://nutritionfacts.org/subscribe/ In case you missed the previous video, check out Effects of Smoking Marijuana on the Lungs (http://nutritionfacts.org/video/effects-of-smoking-marijuana-on-the-lungs). Here's my other cannabis videos that are up so far: • The Institute of Medicine Report on the Health Effects of Marijuana (http://nutritionfacts.org/video/The-Institute-of-Medicine-Report-on-the-Health-Effects-of-Marijuana) • Researching the Health Effects of Marijuana (http://nutritionfacts.org/video/Researching-the-Health-Effects-of-Marijuana) • Is Marijuana Addictive? (http://nutritionfacts.org/video/Is-Marijuana-Addictive) • Does Marijuana Cause Health Problems? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Health-Problems) • Does Marijuana Cause Permanent Brain Damage in Teens? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Permanent-Brain-Damage-in-Teens) • Does Marijuana Cause Permanent Brain Damage in Adults? (http://nutritionfacts.org/video/Does-Marijuana-Cause-Permanent-Brain-Damage-in-Adults) • Will Cannabis Turn into Big Tobacco? (http://nutritionfacts.org/video/will-cannabis-turn-into-big-tobacco) • Marijuana Legalization and the Opioid Epidemic (http://nutritionfacts.org/video/Marijuana-Legalization-and-the-Opioid-Epidemic) All my future upcoming cannabis videos can be streamed right now for a donation to the 501c3 nonprofit that runs NutritionFacts.org. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/smoking-marijuana-vs-using-a-cannabis-vaporizer and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at http://nutritionfacts.org/video/smoking-marijuana-vs-using-a-cannabis-vaporizer. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. If you’d rather watch these videos on YouTube, subscribe to my YouTube Channel here: https://www.youtube.com/subscription_center?add_user=nutritionfactsorg Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages. To find yours, click on the settings wheel on the lower-right of the video and then "Subtitles/CC." Do you have feedback about the translations in this video? Please share it here along with the title of the video and language: https://nutritionfacts.zendesk.com/hc/requests/new To view the subtitles in transcript format, click on the ellipsis button below the video, choose "Open transcript", and select the language you'd like to view them in. Thumbnail credit: Vaping360 http://vaping360.com/. https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Facebook: www.facebook.com/NutritionFacts.org • Twitter: www.twitter.com/nutrition_facts • Instagram: www.instagram.com/nutrition_facts_org • Books: https://nutritionfacts.org/books • Shop: https://drgreger.orgFlying Monkey Watermelon Zkittles Weed Gummies Are Bomb When Osama Binladin Attacks Hes Alive AgainCosmic Razzle Delta 8 Gummies from Space Panda Helps with Leveling up YOUR Gaming and More ⚠️Disclaimer⚠️ I am not a medical specialist. If you have any Questions, seek your medical provider before consuming. 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