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The Science behind Marijuana (Cannabis), Marijuana mechanism of action. Source of information: National Institute on Drug Abuse; National Institutes of Health; U.S. Department of Health and Human Services. Purchase a license to download a non-watermarked version of this video on AlilaMedicalMedia(dot)com Check out our new Alila Academy - AlilaAcademy(dot)com - complete video courses with quizzes, PDFs, and downloadable images. Voice by: Sue Stern Animation ©Alila Medical Media. All rights reserved. Marijuana, also known as cannabis, among other names, is a preparation of the Cannabis sativa plant - the hemp plant, intended for recreational and medicinal uses. The main psychoactive chemical in marijuana is delta-9-tetrahydro-cannabinol, or THC. The Cannabis plant preparation also contains other compounds that are chemically related to THC, called cannabinoids. THC is chemically similar to a class of substances found naturally in our nervous system called endogenous cannabinoids, or endocannabinoids, of which anandamide is best known so far. The endocannabinoids are part of a newly discovered system named the Endocannabinoid system, or ECS. How the ECS works The ECS acts as a modulator of neurotransmission. When the postsynaptic neuron is activated, endocannabinoids are produced, released, and travel back to the presynaptic neuron where they activate cannabinoid receptors. By doing so, they control what happens next when the presynaptic cell is again stimulated. The general effect is a decrease in the release of neurotransmitters such as GABA or glutamate. In other words, the ECS acts as a “brake”, slowing down neuronal activities, preventing neurons from excessive firing. Some examples of ECS functions include: - Pain modulation: cannabinoids suppress pain signal processing, producing pain relief effects. - Stress and anxiety reduction: The ECS has been implicated in the habituation the body’s response to repeated exposure to restraint stress. - Mood regulation: the ECS promotes “good feeling” by inducing dopamine release in the brain reward pathway. This explains the euphoria, or the “high”, experienced by marijuana users. THC mode of action is however different from other drugs: it induces dopamine release INDIRECTLY by removing inhibitory action of GABA on dopaminergic neurons. The ECS is also involved in many more bodily activities, including appetite, memory, learning, sleeping patterns, immune functions and fertility. So how can marijuana be harmful if it does exactly what our body already does to itself? The endocannabinoids are short-acting transmitter substances. They are synthesized on demand and their signaling is rapidly terminated by specific enzymes. Marijuana users consume a much higher amount of THC. THC is also much more stable and can persist in the body for a longer period of time. THC overwhelms the EC system, overriding normal brain functions. Because cannabinoid receptors are present in many parts of the brain and body, the effects of THC are wide-ranging. It can slow down a person’s reaction time, which could impair driving or athletic skills; disrupt short-term memory and higher thought processes, which could affect learning capabilities and judgment ability. Higher doses of THC may also lead to reverse effects. Consuming marijuana by smoking may also damage the lungs to a similar extent as smoking cigarettes. Long - term effects of THC Substantial evidence from animal research indicates that marijuana exposure can cause long-term adverse changes in the brain. Long-term effects of marijuana in human are still debatable mostly due to difficulties of conducting research in human beings. Medical uses of marijuana While recreational use of marijuana is without doubt harmful, the Cannabis plant may be a valuable source of medicines. Currently, the two main cannabinoids from the marijuana plant that are of medical interest are THC and cannabidiol, or CBD. These chemicals are used to increase appetite and reduce nausea in patients undergoing cancer chemotherapy. They may also be useful in reducing pain and inflammation, controlling epileptic seizures, and possibly even treating autoimmune diseases and cancers.

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CBD vs THC A brief history by OP6CBD How they differ! CBD stands for cannabidiol. It is a compound found in the cannabis plant, Cannabis sativa. Unlike (THC) tetrahydrocannabinol, which is the psychoactive component of cannabis, CBD does not produce a "high". CBD (cannabidiol): A non-psychoactive compound found in the cannabis plant. Marijuana: A type of cannabis plant that contains high levels of the psychoactive compound tetrahydrocannabinol (THC). In the United States, cannabis is legal in 39 of 50 states for medical use and 24 states for recreational use. CBD has been used for centuries in traditional medicine for various purposes, including pain relief, anxiety, and seizures. In recent years, CBD has gained popularity as a natural remedy for a wide range of conditions. However, it's important to note that scientific evidence supporting these claims is limited. Cannabis has been around for a very long time, and it has been used in a medicinal capacity in some form since as far back as 2727 BC. But in the English-speaking world, it’s been grown mainly for its fiber. “Hemp,” which is the Old English word for the cannabi After the turn of the 20th century, some activist groups sought to outlaw marijuana, the intoxicating type of cannabis bred for high THC content. However, all hemp production in America eventually became a target. This was a result of the outright lies and racist propaganda spread by things like the infamous Reefer Madness film as well as the inaccurate belief that there is no difference between marijuana and hemp. This led to the Marihuana Tax Act of 1937, which meant that only hemp that had been taxed and approved by the government could be grown or sold. And it was just after 1937 that CBD made its first appearance. In 2018, the U.S. Congress passed and signed the Agriculture Improvement Act into law. This law removed hemp from the federal Controlled Substances Act, effectively legalizing CBD if it comes from hemp. During World War II, hemp was extensively used by several nations, particularly the United States, as a crucial industrial crop to produce fibers for ropes, canvas, uniforms, and other military supplies due to its high fiber content, especially when other sources like imported materials were limited by wartime shortages; this was often referred to as the "Hemp for Victory" campaign to address the need for domestic fiber production. CBD's potential to alleviate chronic pain may be attributed in part to its anti-inflammatory properties. https://op6cbd.com/

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